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BioNukleo GmbH Logo

BioNukleo GmbH

Actively managed by company

At BioNukleo, we harness the power of enzymes to provide sustainable solutions for the synthesis of nucleoside and nucleotide derivatives. By combining our extensive knowledge about biocatalysis and nucleosides we can provide custom biocatalytic solutions with high selectivity and reduced environmental impact, aligning with the demand for sustainable chemical manufacturing. Together with partners we develop processes for customers up to the industrial scale. When BioNukleo was founded in 2014 as a spin-off of the Department of Bioprocess Engineering of the Technische Universität Berlin, we were already looking back on years of academic research on enzymatic production of nucleosides and the production of difficult-to express proteins. Since then BioNukleo has developed into a specialist in biocatalysis and its applications in the synthesis of nucleoside and nucleotide derivatives and other fine chemicals. We are a growing team of young and aspiring scientists and engineers with backgrounds in biology, biotechnology, biochemistry, chemistry, bioinformatics, and pharmaceutical sciences. BioNukleo is located in Germany's beautiful capital city Berlin. At BioNukleo, we harness the power of enzymes to provide sustainable solutions for the synthesis of various fine chemicals, focusing on nucleoside and nucleotide derivatives and related compounds. The German capital region is one of the world's leading locations in healthcare and life science innovation. Our custom biocatalytic solutions offer high selectivity and reduced environmental impact, aligning with the demand for sustainable chemical manufacturing. Our experienced team works closely with customers to optimize processes, develop custom enzymes, and deliver superior results.

Quick overview

Berlin, Germany

Founded in 2014

1-10 Employees

Additional information

Working industry

Biotechnology, Chemicals, Pharmaceuticals, Research

Type of company

Manufacturer, Service provider

Locations

1 Headquarter

Number of products

6 Products

Number of services

2 Services

Specialised areas

nucleic acid derivatives, bioprocess development, nucleoside analogs, nucleotide analogs, thermostable enzymes, sugar-1-phosphates, Biotechnology, biocatalysis

Products & services of BioNukleo GmbH

BioNukleo GmbH offers a wide range of products and services

Product: Acetyl Phosphate

Product

Acetyl Phosphate

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Product: PyNP - Pyrimidine Nucleoside Phosphorylase

Product

PyNP - Pyrimidine Nucleoside Phosphorylase

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Product: PNP - Purine Nucleoside Phosphorylase

Product

PNP - Purine Nucleoside Phosphorylase

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Product: PPK - Polyphosphate Kinase

Product

PPK - Polyphosphate Kinase

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Product: NMPK - Nucleoside Monophosphate Kinase

Product

NMPK - Nucleoside Monophosphate Kinase

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Product: Nucleoside to NTP enzyme cascades

Service

Nucleoside to NTP enzyme cascades

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Product: NTP - Custom Synthesis

Service

NTP - Custom Synthesis

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Product: 5fo-dCTP

Product

5fo-dCTP

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ESG score estimation

An estimation about the ESG values based on digital data and signals. Important: The ESG scores are only based on information about the country, not the actual company itself

Country:

Germany


Overall risk estimation:

Very low


ESG country scores

The ESG Data of countries are based on public sources

Environment

A

Grade (A-E)

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Social

A

Grade (A-E)

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Governance

A

Grade (A-E)

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Use Cases of BioNukleo GmbH

Get insights into the use cases of BioNukleo GmbH

UseCase: AcP/AcK-based ATP Regeneration System

Use case

AcP/AcK-based ATP Regeneration System

Biotechnology, Pharma, Biochemistry, Biocatalysis, Green Chemistry

Many enzymatic reactions require ATP as a co-substrate, and the availability of ATP can be a limiting factor in biocatalytic processes. To overcome this challenge, ATP regeneration systems have been developed, enabling sustainable and cost-effective biocatalytic synthesis. ATP regeneration systems involve coupling the desired biocatalytic reaction with an ATP-generating enzyme. These ATP-generating enzymes are carefully selected and optimized to work in tandem with the target biocatalyst, allowing for efficient and continuous ATP recycling during the biocatalytic process. Advantages of ATP regeneration: Ensuring constant adequate ATP levels throughout the process generally improves yield and reaction velocity of an enzymatic reaction. ATP regeneration may be used to reduce starting ATP levels to overcome inhibitory effects in single or coupled reactions. By utilizing renewable and inexpensive substrates for ATP generation, ATP regeneration systems can reduce the reliance on costly and resource-intensive sources of ATP. There are different possibilities for enzymatic ATP regeneration: Acetate kinase using acetyl phosphate as phosphate donor Creatine kinase using creatine phosphate as phosphate donor Pyruvate kinase using phosphoenolpyruvate as phosphate donor Polyphosphate kinase using polyphosphate as phosphate donor

Headquarter of BioNukleo GmbH

BioNukleo GmbH operates in 1 country around the world

City: Berlin

State: -

Country: Germany

Locations of BioNukleo GmbH

Get an overview of the locations of BioNukleo GmbH

Location

Country

State

City

Headquarter

Germany

-

Berlin

Frequently asked questions (FAQ) about BioNukleo GmbH

Some frequent questions that have been asked about BioNukleo GmbH

The company headquarter of BioNukleo GmbH is located in Berlin, Germany. It's worth noting, that the company may have more locations

As of the latest available information BioNukleo GmbH has around 1-10 employees worldwide.

BioNukleo GmbH was founded in 2014

The company BioNukleo GmbH has it's main focus in the industries of Biotechnology, Chemicals, Pharmaceuticals, Research

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