Orio Therapeutics

Most protein-based therapeutics in regenerative medicine have limited success due to uncontrolled drug delivery, which can result in side effects and high costs. Our technology modifies therapeutic proteins to improve delivery through controlled localization, for enhanced efficacy and reduced dosage. The limited clinical success of many protein-based therapeutics is often due to subpar delivery systems. The injected molecule tends to quickly diffuse away from the injection site, which is a problem especially in regenerative medicine where local action is crucial for tissue regeneration and repair.Our technology solves this issue by allowing precise control over the delivery of the medication. By modifying therapeutic proteins to incorporate a built-in delivery system, we ensure they remain at the targeted injection site. The absence of optimal delivery system usually calls for large doses of therapeutic protein to be administered. As a first application we developed a molecule protecting the cardiac muscle following a heart attack, reducing fibrosis and cellular death, and preserving the cardiac function.