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Hycult Biotechnology (H.B.T.) B.V.
Uden, Netherlands
11-50 Employees
1994
We are proud to be a leading manufacturer of innate immunity research reagents, with a special focus on complement pathways. Our mission has always been to find answers to your questions and work towards improving health. We are committed to supporting scientists worldwide in their research on human diseases. Our products are co-developed with leading scientists, and our strong collaborations with them, coupled with accurate quality control measures, lead to the production of reliable and reproducible research tools. By using our products, you can gain better insights into diseases, aiding in their understanding and monitoring. We have been fulfilling this mission since 1994. Our team possesses extensive expertise in the development and production of assays, antibodies, and proteins. Hycult Biotech prides itself on offering personalized services, high quality products, flexible quantities, and fast delivery times.
Product
Arginase-I, Human, ELISA kit
Zeta Corporation - Target-validated and Characterized Monoclonal Antibody Company
Arcadia, United States
1-10 Employees
2003
We provide the highest quality of antibodies to help pathologists diagnose human tumors and diseases. We are proud of our commitment to producing highly specific, target-validated, and characterized IVD primary biomarkers to aid pathologists in the differential diagnosis of various tumors. Zeta Corporation is an ISO 13485:2016 and FDA registered biomedical company that manufactures and distributes IVD antibodies for Pathology/IHC. Zeta Corporation sells the products directly in the US and distributes them to over 50 different countries globally through our trusted partners. Zeta offers CE-IVD labeled products with European regulatory compliance and encourages distributors to register the products in the individual territories as needed. Provide the highest-quality diagnostic IVD antibodies assisting diagnosis, targeted therapy, and differential diagnosis of human diseases. Zeta Corporation is a biomedical company based in Southern California with ISO 13485 and FDA certifications. Zeta develops, manufactures, and distributes highly specific and sensitive IVD antibodies for Pathology/IHC on FFPE tissue sections.
Product
Arginase-1
Fagus Antibody Services
Oxford, United Kingdom
1-10 Employees
2022
We deliver a service starting from hybridoma creation from your selected antigen, through screening and culture, to purification of the chosen clones. Each part of our service can be utilised independently, such as growth and/or purification of your own hybridoma, or conjugation of your own antibody or one chosen from our own range. Our goal is to be recognised for the science we do and to have a track record of success for our clients. We provide complete cost-effective services for the development and production of antibodies. Fagus Antibody Services is made up of a team of experienced scientists to provide a complete package in antibody development.
Product
Recombinant Human Arginase-1/ARG1 Protein (His & MYC Tag)
Bioss Inc.
Woburn, United States
1-10 Employees
2010
We are excited about the launch of AbBy Fluor®dyes. Bioss Inc is a leading antibody developer and manufacturer with state of the art technologies. We have developed over 11,000 primary antibodies and more than 130,000 derived products including fluorochrome conjugated antibodies.
Product
Arginase 2 Polyclonal Antibody
Genebio
-
- Employees
-
We are happy to announce that we are an official supplier for the Canadian Government. We are passionate about providing customers with outstanding value for money. With upto 75% OFF on products, we want to help you save big this year! GeneBio Systems is a team of specialists dedicated to providing high-performance, and cost-effective products. We strive to serve the scientific community by offering laboratory products for both clinical and academic research. Supporting some of the most research-intensive institutions in Canada, we are committed to fufilling laboratory needs in all aspects of Molecular and Cellular Biology. Established in 2011 in Toronto Ontario, GeneBio Systems is a small yet rapidly growing company in the biotechnology industry. GeneBio Systems prides itself on the value, quality, and customer service it provides through its products and services.
Product
Recombinant Mouse Arginase-1(Arg1)
Antibodies.com
Cambridge, United Kingdom
11-50 Employees
2015
Antibodies.com supplies high-quality biological reagents to life science researchers at cost-effective prices. How do our antibodies compare to their relabelled counterparts from Abcam, Novus Biologicals, Sigma Aldrich, and Thermo Fisher? How do our antibodies compare to those from Abcam, Novus Biologicals, Sigma Aldrich, and Thermo Fisher? Learn how isotype control antibodies are used to determine the level of background staining due to non-specific antibody binding. Our growing product range caters for every discipline and includes: primary antibodies, secondary antibodies, proteins and peptides, immunoassays and kits, and other companion products. Immunocytochemistry of U251 cells using different Anti-GFAP Antibodies. Immunocytochemistry of K562 cells using different Anti-Vimentin Antibodies.
Product
Anti-liver arginase/ Antibodies
Cell Signaling Technology
Danvers, United States
251-500 Employees
1999
Cell Signaling Technology (CST) is dedicated to providing the world’s highest quality, innovative research products to accelerate biological understanding. Founded in 1999, CST employs over 600 people worldwide. To show local product price and availability and for ordering, we are taking you now to our secure CST Portal. Cell Signaling Technology® Products are Prevalent in CiteAb's Top Antibodies of 2022.
Product
Arginase-2 (D9J1N) XP® Rabbit mAb #55003
MS Validated Antibodies GmbH
Hamburg, Germany
1-10 Employees
2020
Many antibody vendors provide very little information and images on how an antibody stains. MS Validated Antibodies is devoted to delivering optimal monoclonal antibodies for immunohistochemistry and to provide the users with a unique product documentation enabling them to know as much as possible on their antibodies. These share the advantage of complete reproducibility of their production because they are not generated by potentially unstable hybridoma cells but produced “in lab” based on the known DNA sequence of the antibody chains. CPA1 (clone MSVA-601M) is a new marker for immunohistochemistry with very high sensitivity and specificity (>99%) for acinar cell carcinoma of the pancreas. Stay up-to-date with our new products and all relevant „Large-Scale Studies“ using MSVA Antibodies!
Product
Arginase 1 (MSVA-511R)
Biotium
Fremont, United States
11-50 Employees
2001
Biotium is a leading life science reagent manufacturer and supplier devoted to providing high-quality and innovative fluorescent tools that fuel scientific discovery. Biotium is uniquely poised to invent cutting-edge products through the synergy of chemistry and biology. Biotium is based in the San Francisco Bay Area, with distribution channels across the globe. Biotium has licensed many of its patented technologies to a number of major international biotech companies including Agilent, BD Biosciences, Biolegend, BioRad, EMD Millipore, Illumina, PerkinElmer, Qiagen, Roche, Sartorius AG, Sigma-Aldrich, Thermo Fisher Scientific, and several others. These partnerships extend Biotium’s reach to more customers and expand applications of Biotium’s cutting-edge technologies in life science research, medical diagnostics, and pharmaceutical science. Biotium is certified under an ISO 9001:2015 quality management system. Biotium's new BactoSpore™ Bacterial Stains were developed to tackle the challenge of endospore detection by offering bright staining of endospores as well as live and dead bacteria for microscopy or flow cytometry. A leading provider of innovative fluorescent solutions for scientists.
Product
Arginase 1 Monoclonal Mouse Antibody (ARG1/1125)
RevMAb Biosciences
South San Francisco, United States
1-10 Employees
2012
RevMAb Biosciences USA, Inc is located in heart of South San Francisco, the biotechnology hub of the Bay Area, and home to many of the largest and most successful biotechnology and pharmaceutical companies in the world.
Product
Anti-Arginase-1 (ARG1) Rabbit Monoclonal Antibody, Clone RM377
Technologies which have been searched by others and may be interesting for you:
Some interesting numbers and facts about your company results for Arginase
| Country with most fitting companies | United States |
| Amount of fitting manufacturers | 1490 |
| Amount of suitable service providers | 1019 |
| Average amount of employees | 51-100 |
| Oldest suiting company | 1993 |
| Youngest suiting company | 2020 |
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Arginase is a manganese-containing enzyme that catalyzes the hydrolysis of arginine to ornithine and urea, marking the final step in the urea cycle, a critical process for the detoxification of ammonia in the liver. Present in two isoforms, arginase I and arginase II, these enzymes have distinct cellular localizations and physiological roles. Arginase I is primarily found in the cytosol of liver hepatocytes and plays a pivotal role in the urea cycle, facilitating ammonia detoxification and urea production for excretion. On the other hand, arginase II is located in the mitochondria of various tissues, including the kidneys, brain, and small intestine, where it participates in the polyamine synthesis pathway, crucial for cell proliferation and repair. The enzymatic activity of arginase has significant implications in multiple physiological and pathological processes, including immune response regulation, tissue repair, and the pathogenesis of certain diseases such as asthma, cancer, and cardiovascular disorders. By modulating arginine availability, arginase indirectly influences nitric oxide production and polyamine synthesis, which are vital for vascular tone regulation, immune function, and cellular growth. Consequently, understanding arginase's function and regulation offers potential therapeutic targets for treating diseases associated with dysregulated arginine metabolism and nitric oxide synthesis.
1. Enhanced Wound Healing
Arginase plays a crucial role in accelerating the wound healing process. By breaking down arginine, it facilitates the production of proline, an amino acid essential for the synthesis of collagen. This action not only speeds up tissue repair but also improves the strength and flexibility of the newly formed tissue, making it a superior option for post-surgical recovery or skin injuries compared to alternatives that lack this mechanism.
2. Improved Immune System Function
The enzyme supports the immune system by modulating the production of nitric oxide, a compound critical for defending the body against pathogens. By regulating nitric oxide levels, arginase helps maintain an optimal balance, preventing excessive inflammatory responses that can harm the body, offering a more refined approach to boosting immunity than other immune-supporting supplements.
3. Better Management of Metabolic Conditions
Arginase aids in the urea cycle, helping to remove ammonia from the body. This function is particularly beneficial for individuals with certain metabolic disorders, as it assists in reducing ammonia levels, thereby preventing potential neurotoxic effects. Compared to other treatments that might not directly influence ammonia clearance, arginase provides a targeted approach, making it an invaluable tool in managing these conditions.
While evaluating the different suppliers make sure to check the following criteria:
1. Production Capacity
Ensure the supplier has the capability to meet your volume requirements without compromising quality. Large-scale production abilities indicate a supplier's reliability and scalability.
2. Purity Levels
Verify the purity level of the Arginase offered. High purity is crucial for research and pharmaceutical applications to ensure accurate results and effectiveness.
3. Regulatory Compliance
Check that the supplier adheres to international standards and regulations, including ISO certification and FDA guidelines, to guarantee product safety and quality.
4. Cost-Effectiveness
While quality should not be compromised for cost, competitive pricing is essential. Evaluate if the supplier offers favorable pricing without hidden charges.
5. Technical Support and Customer Service
Assess the supplier's commitment to providing technical support and customer service. Quick and knowledgeable responses to queries can be a significant advantage.
6. Shipping and Handling Procedures
Ensure the supplier has robust shipping and handling protocols to maintain product integrity during transit, especially for temperature-sensitive products like Arginase.
Arginase plays a crucial role in the pharmaceutical industry, serving as a key enzyme in the urea cycle. By converting L-arginine into urea and L-ornithine, it aids in detoxifying ammonia in the liver. This enzymatic process is fundamental for developing treatments for liver diseases and certain genetic disorders where ammonia accumulation is a problem. Pharmaceutical companies harness arginase to create medications that help manage these conditions, improving patient outcomes and quality of life. In the field of biotechnology, arginase finds its application in the production of L-ornithine, a compound used in dietary supplements and as a precursor in the manufacturing of polyamides. Biotech firms exploit the enzyme's ability to efficiently produce L-ornithine from L-arginine, streamlining production processes and reducing costs. This application not only supports the dietary supplement market but also contributes to innovations in biodegradable plastics and other environmentally friendly materials. Additionally, arginase is increasingly recognized in cancer research for its role in modulating the immune system. By depleting L-arginine, arginase can suppress immune responses, a mechanism that tumors exploit to evade detection. Understanding this interaction opens avenues for developing immunotherapies that inhibit arginase, thereby enhancing the body's ability to fight cancer. Companies specializing in oncology are exploring arginase inhibitors as potential treatments, aiming to boost the efficacy of cancer immunotherapy.
Arginase, an enzyme pivotal in the urea cycle, converting L-arginine into urea and L-ornithine, currently sits at varying Technology Readiness Levels (TRLs) depending on its application domain. For its traditional biochemical role in liver function and diagnostics, arginase can be considered at a high TRL, approximately 8 or 9, because it is well-integrated into clinical practices with fully developed and validated diagnostic tests available. This high TRL is supported by decades of research, a comprehensive understanding of its biochemical pathways, and its established utility in diagnosing liver function abnormalities. However, when considering arginase as a therapeutic target or its use in novel applications such as in cancer immunotherapy, its TRL is significantly lower, likely around 2 to 4. This is primarily due to the ongoing research and development phase, focusing on understanding the enzyme's complex role in immune system modulation and tumor metabolism. The technical challenges in these areas include optimizing enzyme inhibitors, ensuring specificity, understanding the systemic effects of modulation, and developing effective delivery mechanisms. These challenges reflect the early-stage exploration and validation of arginase's therapeutic potential, indicating a nascent but rapidly evolving TRL in these innovative applications.
In the Short-Term, advancements in arginase technology are expected to focus on enhancing enzyme stability and activity for therapeutic applications. Researchers are developing novel arginase formulations and delivery mechanisms, such as encapsulated enzymes or targeted delivery systems, that can maintain enzymatic activity longer in the human body. This progress aims to improve treatments for disorders like arginase deficiency and certain types of cancer, where arginase plays a crucial role in modulating the immune response. The Mid-Term forecast sees the integration of biotechnological innovations with arginase research, leading to genetically modified organisms (GMOs) capable of producing human-compatible arginase in large quantities. This approach not only promises to reduce production costs significantly but also improves the scalability of treatments. Additionally, the development of arginase inhibitors as a novel class of drugs is anticipated to advance, offering potential therapeutic options for diseases where arginase activity needs to be controlled, such as in certain cardiovascular and inflammatory diseases. Looking into the Long-Term, the focus will likely shift towards the application of artificial intelligence and machine learning in predicting and enhancing the interactions of arginase with various substrates and inhibitors. These technologies are expected to revolutionize the design of arginase-based drugs by allowing for highly personalized medicine, targeting specific pathways with unprecedented precision. Moreover, the exploration of arginase's role in aging and longevity could open new frontiers in gerontology, potentially leading to breakthroughs in extending human lifespan and enhancing quality of life in the elderly.
Some interesting questions that has been asked about the results you have just received for Arginase
What are related technologies to Arginase?
Based on our calculations related technologies to Arginase are Aromatics, Desiccants, Refrigerants, Resins, Green Chemistry
Who are Start-Ups in the field of Arginase?
Start-Ups who are working in Arginase are
Selenozyme
Which industries are mostly working on Arginase?
The most represented industries which are working in Arginase are Biotechnology, Other, Pharmaceuticals, Healthcare, IT, Software and Services
How does ensun find these Arginase Companies?
ensun uses an advanced search and ranking system capable of sifting through millions of companies and hundreds of millions of products and services to identify suitable matches. This is achieved by leveraging cutting-edge technologies, including Artificial Intelligence.
