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Genzyme Diagnostics
Framingham, United States
251-500 Employees
1981
We are a solid partner for healthcare professionals, distributors, and manufacturers worldwide with state-of-the-art manufacturing facilities and international sales and distribution networks. We are part of the SEKISUI Medical Group; a diverse, global network committed to improving health outcomes and the well-being of people worldwide. We are committed to upholding ethical work practices across our business—whether that’s sourcing raw materials from suppliers we trust to uphold basic human rights, to our work internally supporting healthy work/life balance for our employees. We provide you with the solutions, products, and education you need to improve patient outcomes. We value and respect differences among all employees, and promote a trusting, collaborative, and productive working environment that enables us to operate our global workplace with a sense of unity. We create innovative solutions that impact the health of all people. Our leadership team is staffed with industry experts, experienced professionals, and hardworking motivators dedicated to furthering our culture of innovation. Our global reach allows us to form relationships that help us refine and innovate products and services to constantly improve the quality of results we deliver.
Product
Hexokinase
Sorachim SA
Lausanne, Switzerland
11-50 Employees
1975
Product
Hexokinase
Genebio
-
- Employees
-
We are happy to announce that we are an official supplier for the Canadian Government. We are passionate about providing customers with outstanding value for money. With upto 75% OFF on products, we want to help you save big this year! GeneBio Systems is a team of specialists dedicated to providing high-performance, and cost-effective products. We strive to serve the scientific community by offering laboratory products for both clinical and academic research. Supporting some of the most research-intensive institutions in Canada, we are committed to fufilling laboratory needs in all aspects of Molecular and Cellular Biology. Established in 2011 in Toronto Ontario, GeneBio Systems is a small yet rapidly growing company in the biotechnology industry. GeneBio Systems prides itself on the value, quality, and customer service it provides through its products and services.
Product
Recombinant Human Hexokinase-1(HK1)
BGENZ.com
Cairo, Egypt
1-10 Employees
2021
Product
Human Hexokinase II ELISA Kit- 96 Tests
Supa Hot Crew
Germany
1-10 Employees
2013
We are a team of scientists and engineers who are passionate about enzymes. That's why we developed high quality enzyme products that are easy to use and reliable. We are enzyme.bio, a team of scientists who are passionate about enzymes. We believe in the power of enzymes and their ability to help bio firms and labs achieve their goals. We're committed to providing the best possible products and service to our customers. Dr Cao leads the research and production of our company. We believe in their power to make a difference in the world, and we’re committed to providing the highest quality diagnostic enzymes, food enzyme to our lab and biotech customers.
Product
Glucose (GLU) (Hexokinase Method) Assay Kit – Bulk Reagents
Huabio
Huron Charter Township, United States
101-250 Employees
2007
Learn about the processes and extra steps we take to deliver the highest performing antibodies straight to your bench. Alternatively use it as a simple call to action with a link to a product or a page.
Product
Hexokinase II Rabbit Polyclonal Antibody (HA500186)
Fagus Antibody Services
Oxford, United Kingdom
1-10 Employees
2022
We deliver a service starting from hybridoma creation from your selected antigen, through screening and culture, to purification of the chosen clones. Each part of our service can be utilised independently, such as growth and/or purification of your own hybridoma, or conjugation of your own antibody or one chosen from our own range. Our goal is to be recognised for the science we do and to have a track record of success for our clients. We provide complete cost-effective services for the development and production of antibodies. Fagus Antibody Services is made up of a team of experienced scientists to provide a complete package in antibody development.
Product
Rat HK1(Hexokinase 1) ELISA Kit
Innovative Research
Novi, United States
11-50 Employees
1998
We are happy to help you find exactly what you need to keep your research going. Innovative Research was established more than 20 years ago after the realization that dependable, high-quality, and affordable research materials were hard to come by. Innovative Research has been an industry-leading, privately-owned supplier of biological research reagents for over two decades. Since those humble beginnings the company has greatly expanded its product offerings and along the way has experienced tremendous growth. Innovative Research currently manufactures and supplies researchers with over 25,000 high-quality human and animal biologics including blood products, tissues, proteins, polyclonal and monoclonal antibodies, ELISA kits, viral transport media and more. For over twenty years, Innovative Research has placed customer service as our highest priority. Through this acquisition, Innovative Research is able to leverage Molecular Innovation's decades of experience and cutting edge technology in manufacturing research biologicals to further improve the quality and production processes of their products. Read the Press Release to find out more details regarding the acquisition and Innovative Research's vision moving forward.
Product
Yeast-Derived Hexokinase Purified Lyophilized
Autorenwelt
Germany
1-10 Employees
2015
Product
Optimierung der Produktion und Aufarbeitung von Glucose-6-phosphat Dehydrogenase und Hexokinase aus Bäckerhefe
CellSystems Biotechnologie Vertrieb
Troisdorf, Germany
11-50 Employees
1992
That is why we are always at your side with competent advice. Good accessibility We are there for you on weekdays from 9.00 to 17.00. CellSystems` product portfolio comprises a range of products for cell biology research and in vitro toxicology studies. Founded in 1992 as a sales and marketing organization for primary cells and selective media (cell-systems), CellSystems is today your European partner for life science research products. Looking back at nearly 30 years of experience with highly sophisticated research products in this challenging market, we know from our own experience the importance of reproducibility, batch to batch consistency, and reliability, but also the significance to comply with cold chain requirements, import and export regulations, veterinarian approval, ISO certified processes and further important standards. Knowing that every experimental setup and protocol varies to a certain grade, our experts are here to support your science with our comprehensive experience with each single product. To ensure that you get the right product for your application, we will be happy to assist you in detail regarding various possible applications. You have product related questions or like to start an inquiry?
Product
Glucose-6-Phosphate Dehydrogenase, High-Activity, Suspension -
Technologies which have been searched by others and may be interesting for you:
Some interesting numbers and facts about your company results for Hexokinase
| Country with most fitting companies | Germany |
| Amount of fitting manufacturers | 1141 |
| Amount of suitable service providers | 855 |
| Average amount of employees | 1-10 |
| Oldest suiting company | 1991 |
| Youngest suiting company | 2021 |
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Hexokinase is a pivotal enzyme that catalyzes the first essential step in the glycolytic pathway, a fundamental process in cellular metabolism. This enzyme facilitates the conversion of glucose, a primary energy source for cells, to glucose-6-phosphate (G6P). By doing so, hexokinase effectively traps glucose within the cell and marks the beginning of its metabolic breakdown, which is crucial for energy production in both aerobic and anaerobic conditions. The significance of hexokinase extends beyond energy metabolism; its activity is also intricately linked to the regulation of glucose levels in the blood, making it a key player in maintaining cellular energy homeostasis. Given its role, alterations in hexokinase activity or expression can have profound implications for cellular function and are associated with various diseases, including diabetes and cancer. In cancer cells, for instance, elevated levels of hexokinase can lead to increased glucose metabolism, a phenomenon known as the Warburg effect, highlighting the enzyme's potential as a target for therapeutic intervention. Understanding the function and regulation of hexokinase is, therefore, of paramount importance in the fields of biochemistry and medical research, as it continues to inform strategies for disease management and therapeutic development.
1. Enhanced Glucose Processing Efficiency
Hexokinase plays a pivotal role in the first step of glycolysis, offering a more efficient glucose processing capability compared to its counterparts. This enzyme has a high affinity for glucose, ensuring that even at low concentrations, glucose can be effectively phosphorylated, facilitating a steady supply of energy for cellular processes.
2. Broad Substrate Specificity
Unlike other glucose-processing enzymes, hexokinase demonstrates a remarkable ability to phosphorylate multiple hexoses besides glucose. This broad substrate specificity allows for the utilization of various sugar types within the cell, providing a versatile approach to energy production and metabolic flexibility.
3. Regulation and Feedback Inhibition
Hexokinase activity is finely regulated through feedback inhibition by its product, glucose-6-phosphate. This regulatory mechanism ensures a balanced cellular energy state, preventing the excessive accumulation of glucose-6-phosphate and maintaining efficient metabolic pathways.
4. Low Km Value
The low Km value of hexokinase for glucose signifies its high affinity towards glucose, ensuring effective phosphorylation even when glucose levels are minimal. This characteristic is particularly beneficial under conditions of low blood sugar, supporting consistent energy production and cellular function.
While evaluating the different suppliers make sure to check the following criteria:
1. Purity Levels
Ensure the hexokinase supplied meets high purity standards, as impurities can significantly affect its efficacy in biochemical applications.
2. Source and Origin
Verify the source of the hexokinase, whether it is from a recombinant, bacterial, yeast, or mammalian source, as this can impact its activity and stability.
3. Formulation and Stability
Check the formulation provided by the supplier, including buffer substances and stabilizers used, to ensure long-term stability and activity of the enzyme.
4. Activity Specification
The supplier should provide clear information on the enzyme's activity units per milligram, indicating its ability to catalyze the conversion of substrates.
5. Quality Certifications
Look for suppliers with recognized quality certifications (e.g., ISO, GMP) to ensure the hexokinase meets global quality standards.
6. Technical Support and Documentation
The availability of comprehensive technical support and detailed product documentation is crucial for application success and regulatory compliance.
Hexokinase, an enzyme pivotal in the glucose metabolism process, finds extensive applications across multiple industries, notably in pharmaceuticals and biotechnology. In the pharmaceutical realm, hexokinase's role in glycolysis makes it a critical target for developing diabetes and cancer treatments. By inhibiting or modulating its activity, researchers can potentially control the rate of glucose metabolism in cells, offering therapeutic pathways for conditions characterized by altered glucose utilization. In the biotechnology sector, hexokinase is instrumental in biochemical assays that measure glucose levels in various samples. These assays are vital in research and development, particularly in understanding metabolic diseases and developing corresponding treatments. The enzyme's ability to catalyze the phosphorylation of glucose to glucose-6-phosphate is leveraged in these assays to provide accurate and reliable measurements of glucose concentration. Furthermore, hexokinase's application extends into the food and beverage industry, where it's used in quality control processes. By assessing the glucose content in food products, manufacturers can ensure product consistency and taste, aligning with consumer expectations and regulatory standards. This enzymatic testing is crucial for maintaining the quality and safety of consumable goods, illustrating hexokinase's versatility across different B2B contexts.
Hexokinase, an enzyme pivotal in the glycolysis process, is at a high Technology Readiness Level (TRL), typically TRL 9, as it's widely utilized in both research and industrial applications. This advanced TRL is attributed to the extensive understanding of hexokinase's molecular structure, function, and its role in glucose metabolism, which has been thoroughly explored and documented over years of biochemical and biotechnological research. The enzyme's ability to catalyze the phosphorylation of glucose to glucose-6-phosphate is crucial for cellular metabolism, making it a fundamental component in diagnostic kits for measuring glucose levels in blood and in producing high-fructose corn syrup, a common sweetener. The technical maturity of hexokinase is also evidenced by the development of recombinant forms and inhibitors, which are used in pharmaceutical research to explore therapeutic avenues for diseases like cancer, where altered glucose metabolism plays a critical role. Furthermore, the scalable production and purification methods for hexokinase have been optimized, ensuring its availability and affordability for various applications, ranging from medical diagnostics to bioenergy production. This high TRL reflects the enzyme's robust characterization, broad utility, and the established methods for its production and application in a range of industries.
In the Short-Term, advancements in hexokinase technology are expected to focus on improving enzymatic efficiency and stability. Researchers are leveraging genetic engineering to produce hexokinase variants with enhanced activity and resistance to inhibitors. This phase will likely see the development of novel assay methods for quicker and more accurate hexokinase activity measurement, facilitating rapid diagnostics and research in glycolysis-related metabolic disorders. The Mid-Term outlook includes the integration of hexokinase into bioengineered systems for therapeutic applications. Efforts are being directed towards harnessing hexokinase's pivotal role in glucose metabolism to develop targeted cancer therapies, given its overexpression in various cancer cells. Additionally, biotechnological advancements are anticipated to enable the encapsulation of hexokinase in biocompatible materials, improving its delivery and efficacy in metabolic regulation for diabetes management. Looking into the Long-Term, the horizon is set for the exploration of hexokinase's role in synthetic biology. The enzyme's potential in constructing synthetic pathways for biofuel production is a promising area. Innovations may lead to the development of genetically modified organisms (GMOs) capable of utilizing hexokinase for efficient bioconversion processes, contributing to sustainable energy solutions. Furthermore, long-term research aims to fully understand hexokinase's regulation mechanisms, opening new avenues for manipulating metabolic pathways in disease treatment and biomanufacturing.
Some interesting questions that has been asked about the results you have just received for Hexokinase
What are related technologies to Hexokinase?
Based on our calculations related technologies to Hexokinase are Aromatics, Desiccants, Refrigerants, Resins, Green Chemistry
Who are Start-Ups in the field of Hexokinase?
Start-Ups who are working in Hexokinase are
Alkimi Syrup
Which industries are mostly working on Hexokinase?
The most represented industries which are working in Hexokinase are Other, Biotechnology, Healthcare, Pharmaceuticals, IT, Software and Services
How does ensun find these Hexokinase Companies?
ensun uses an advanced search and ranking system capable of sifting through millions of companies and hundreds of millions of products and services to identify suitable matches. This is achieved by leveraging cutting-edge technologies, including Artificial Intelligence.
