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Genebio
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- Employees
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We are happy to announce that we are an official supplier for the Canadian Government. We are passionate about providing customers with outstanding value for money. With upto 75% OFF on products, we want to help you save big this year! GeneBio Systems is a team of specialists dedicated to providing high-performance, and cost-effective products. We strive to serve the scientific community by offering laboratory products for both clinical and academic research. Supporting some of the most research-intensive institutions in Canada, we are committed to fufilling laboratory needs in all aspects of Molecular and Cellular Biology. Established in 2011 in Toronto Ontario, GeneBio Systems is a small yet rapidly growing company in the biotechnology industry. GeneBio Systems prides itself on the value, quality, and customer service it provides through its products and services.
Product
GB-Cloneâ„¢ T4 DNA Ligase
Xcess Biosciences Inc.
San Diego, United States
1-10 Employees
2012
Xcess Biosciences Inc (XcessBio or Xbio) was founded in 2008 by scientists from academia and BioPharma industry with strong expertise in chemistry and biology. We are dedicated to develop high-quality products and deliver the best services for our customers. We diligently develop high quality products and strive to earn your satisfaction. If you know of any technology, product, or service development opportunities in the fields related, we would be very interested in hearing from you. SD70 is a potent, selective and cell-permeable inhibitor of histone demethylase JMJD2 (KDM4C), identified by phenotypic screening for inhibitors of ligand and genotoxic stress-induced translocations in prostate cancer cells.
Product
E3 ligase Ligand 13
biotechrabbit GmbH
Berlin, Germany
11-50 Employees
2011
You have no items in your shopping cart. biotechrabbit is a team of life science experts providing the highest quality products and customized solutions for your success! Find out how you can benefit from our customized solutions!
Product
Ligases & NA Modifying Enzymes
Intact Genomics
Creve Coeur, United States
1-10 Employees
2013
We are dedicated to empowering scientific discoveries and innovation, developing cutting-edge technologies and innovating life science products for isothermal amplification, gene-editing, simplified molecular cloning and transformation, large DNA fragment cloning and metagenomics. Our products undergo rigorous testing and adhere to stringent quality control measures to ensure accuracy, reliability, and reproducibility in your experiments. Intact Genomics (IG®) is an ISO 13485:2016 certified biotech company that provides high-quality life science products and advanced genomic services to customers around the world. Unrivaled Product Quality: We adhere to the highest industry standards. Whether you have questions about product selection, protocols, or troubleshooting, our dedicated support team is here to assist you every step of the way. Customization Options: We offer customization options for most of our products to meet your specific requirements. Competitive Pricing: Intact Genomics is dedicated to offering competitive pricing without compromising on quality. In Stock & Fast Shipping: All our products are developed, manufactured and shipped from our labs in St.
Product
T4 DNA Ligase
Codexis
Temecula, United States
51-100 Employees
2002
Codexis has engineered IVT enzymes to overcome the obstacles of producing high-quality mRNA at commercial scale. At Codexis, we strive to innovate sustainable processes and products, and discover and develop effective therapeutics – all to create a brighter future. Reimagine enzymes as enablers for efficient pharmaceutical manufacturing, sequencing and diagnostic applications, RNA manufacturing and more. Engineered enzymes can overcome current challenges, bottlenecks and enable new methods for product and process innovations. Engineered, high-quality biocatalysts can transform processes with enhanced activity and stability, leading to efficient and sustainable production of pharmaceuticals. The challenges associated with in vitro transcription (IVT) to manufacture large quantities of mRNA requires high performance enzymes that reduce impurities and produce capped, full-length mRNA. High-performing and specifically tailored for life science research needs, our enzyme products improve processivity, boost efficiency and withstand more challenging condition resulting in faster and more versatile workflows and better yields. We offer research and development partnership options to develop and deliver quality engineered enzyme solutions, providing a path to successful commercialization including screening, proof-of-concept, evolution, and options to scale-up and supply custom enzymes.
Product
CDX Ligase (Pre-commercial) :: Codexis, Inc. (CDXS)
MyBio Ltd
Ireland
1-10 Employees
2009
MyBio is the exclusive supplier of many of the world’s leading bioscience products. MyBio give you easy access to Proteintech’s extensive range of high quality and competitively priced antibodies, cytokines, and other essential research products. A trusted provider of bespoke commercial solutions to partners and customers. Delivering innovative leading edge technologies into the Irish market to enable new discoveries in life sciences. It has the largest proprietary portfolio of self-manufactured antibodies, covering 2/3 of the human proteome. With over 200,000 products cited and confirmed specificity, Proteintech offers antibodies and immunoassays across a wide range of research areas. Proteintech supply over 15,000 products against 13,000 different proteins. This selection currently covers 2/3 of the human proteome and is self manufactured and validated for reproducibility, creating unparalleled quality and uninterrupted supply.
Product
T4 RNA Ligase
Proteros biostructures GmbH
Planegg, Germany
51-100 Employees
1998
We are recognized as experts in our market of early drug discovery research. We are agile in thinking and the way we act. We are fully committed to our clients challenges and drive things forward proactively. We are based in the Martinsried / Munich - Biotech Cluster in Germany. We are very close to our biotech neighbours, pharmaceutical, medical, pharmaceutical university, Max-Planck-Institutes and hospitals, which is very stimulative for scientific networking and translational activities. Proteros is a Munich-based provider of structure-based early stage drug discovery services with a cutting-edge discovery engine tailored to unlock even the most technically challenging drug targets. Proteros supports its clients to reach the right results and accelerate their overall research timelines, helping them to open the door to lead optimization and clinical programs. Proteros' work is built on scientific excellence, having been founded on Nobel prize-winning science.
Product
E3 ubiquitin-protein ligase Mdm2
Lab-JOT® Ltd. Sp.z o.o. Sp.k.
Warsaw, Poland
1-10 Employees
2011
Product
T4 RNA Ligase Reaction Buffer Pack
Ubiquigent Ltd
Dundee, United Kingdom
1-10 Employees
2009
Founded 13 years ago, Ubiquigent has cultivated an unrivalled track record and comprehensive range of specialist services focused on the exploitation of DUBs and the ubiquitin-proteasome system (UPS). As such, we are the partner chosen by many leading industry and academic organisations for their DUB-focused drug discovery and development programmes spanning the fields of protein degradation, stabilisation, and cellular signalling. Ubiquigent benefits from high calibre backing, including from IP Group PLC and Scottish Enterprise. Ubiquigent™ has an unrivalled track record and unique range of specialist services focused on the exploitation of the DUB enzymes and ubiquitin-proteasome system (UPS). Alongside the delivery of specialist services to customers, we have an internal pipeline of drug discovery programmes and are developing a strong IP portfolio encompassing DUB inhibitors, DUB-targeting PROTACs and DUBTACs, providing potential new starting points for client discovery programmes through partnerships and out-licensing agreements. Based in a state-of-the-art facility located in Dundee, Scotland, we sit at the centre of highly relevant additional scientific expertise and capabilities. Laurence is the former Managing Director and co-owner of Tocris Bioscience, a specialist life science reagent business providing bioactive chemicals, peptides and antibodies to researchers worldwide. Ian Ratcliffe founded Stemgent – a stem cell reagent and service company – in 2008 and serves as its Executive Chairman.
Service
E3 Ligases 33 Products
Prokazyme.com
Reykjavik, Iceland
1-10 Employees
2013
Prokazyme produces and sells novel enzymes for research, diagnostic and industrial testing purposes. Prokazyme is based on two decades of geothermal bioprospecting, extremophile genomics and enzyme discovery. Prokazyme (as an SME) and Matis have formed a research alliance and are jointly participating in a number of international research project funded by the European Union. Prokazyme has made a number of agreements with academic groups for marketing of their enzymes and is open for agreements with new academic partners. Prokazyme will consider collaboration in new research projects and is open to discuss possible development of enzymes for specific industrial needs. Prokazyme also continues to make distribution agreements for its products with other companies on the market worldwide. Continued R&D and the strategic alliance with Matis gives Prokazyme the opportunity to exploit vast and growing gene databases for thermophilic bacteria and viruses and to continue to develop new and unique enzyme products.
Product
Rma DNA ligase from Rhodothermus marinus | Prokazyme
Technologies which have been searched by others and may be interesting for you:
Some interesting numbers and facts about your company results for Ligase
| Country with most fitting companies | Netherlands |
| Amount of fitting manufacturers | 924 |
| Amount of suitable service providers | 942 |
| Average amount of employees | 1-10 |
| Oldest suiting company | 2001 |
| Youngest suiting company | 2020 |
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A ligase is an enzyme that plays a crucial role in the process of joining two large molecules by forming a new chemical bond, typically with the consumption of adenosine triphosphate (ATP). This class of enzymes is fundamental in various biological processes, including the repair of DNA strands, replication, and the synthesis of molecules essential for life. In the realm of molecular biology and genetics, ligases are indispensable. For instance, DNA ligase, a well-known type of ligase, is key in connecting Okazaki fragments during DNA replication in eukaryotic cells and in the repair of single-strand breaks that can arise from damage due to radiation or oxidative stress. The action of ligases is not only critical in the natural biological processes but also in biotechnological applications, such as genetic engineering and molecular cloning. Through the precise manipulation of ligases, scientists are able to insert or remove specific DNA sequences, enabling the development of genetically modified organisms (GMOs), therapeutic gene products, and the study of genetic functions. The ability of ligases to facilitate the formation of covalent bonds between nucleic acids or between a nucleic acid and another molecule has significant implications in the development of novel therapies and the understanding of life at the molecular level.
1. Enhanced Precision
Ligases offer remarkable precision in the joining of DNA fragments. Unlike other enzymes that might introduce errors or unwanted mutations, ligases are capable of accurately connecting specific sequences. This precision is critical in genetic engineering and molecular biology, where the exact arrangement of DNA sequences is essential for successful experiments or therapeutic applications.
2. Efficiency in Various Conditions
Another significant advantage is their ability to work efficiently under a wide range of conditions. Ligases can function at different temperatures and pH levels, making them more versatile than alternative enzymes that might require very strict conditions to be effective. This flexibility facilitates their use in various laboratory settings and applications, from basic research to complex diagnostic tests.
3. Low Toxicity
Ligases are known for their low toxicity, which is paramount when working with sensitive samples or in therapeutic contexts. Unlike some chemical methods of DNA joining, which can be harmful to cells or the environment, ligases offer a safer option. This characteristic ensures that the integrity of the biological material is maintained, supporting more accurate and reliable results.
1. Product Quality and Purity
Ensure the supplier has a consistent record of providing high-quality Ligase enzymes with a high level of purity, as this impacts the success of molecular biology applications.
2. Technical Support and Service
Choose a supplier that offers comprehensive technical support, including detailed product documentation and responsive customer service, to assist with any queries or issues.
3. Product Range
Opt for suppliers that offer a wide range of Ligase products, including different types and specifications, to ensure you can find the most suitable enzyme for your specific application.
4. Price and Cost-Effectiveness
While quality should not be compromised, compare prices among suppliers to ensure you are getting the best value for your investment in Ligase enzymes.
5. Delivery and Availability
Confirm the supplier has reliable delivery times and consistent availability of products to avoid delays in your research or project timelines.
6. Reputation and Reviews
Research the supplier’s reputation within the scientific community and read customer reviews to gauge satisfaction levels and reliability.
Ligases are crucial enzymes in the biotechnological and pharmaceutical industries for their role in facilitating the joining of two large molecules by forming a new chemical bond. In drug development, ligases are employed to synthesize novel compounds, enabling the creation of new medications with enhanced efficacy and reduced side effects. This application is vital for companies looking to innovate and improve their product offerings in a competitive market. In the field of genetic engineering, ligases find extensive use in recombinant DNA technology. They are instrumental in splicing genes, allowing for the creation of genetically modified organisms (GMOs) tailored for specific agricultural or medicinal purposes. This capability is particularly beneficial for companies focused on developing crops with increased yield, pest resistance, or nutritional value. Another significant B2B use case involves the use of ligases in the diagnostics industry. These enzymes play a key role in molecular diagnostics, including the detection of genetic mutations and infectious diseases. By facilitating the amplification and identification of specific DNA sequences, ligases enable the development of highly sensitive and accurate diagnostic tests. This application is crucial for healthcare providers and research institutions seeking to improve patient outcomes through precision medicine. Each of these use cases underscores the versatility and importance of ligases across various sectors, highlighting their potential to drive innovation and efficiency in a wide range of industrial applications.
Ligases are enzymes that play a crucial role in molecular biology and biotechnology, catalyzing the joining of two large molecules by forming a new chemical bond, typically with the consumption of ATP. The current Technology Readiness Level (TRL) for ligase applications varies widely across different fields, but in general, it can be considered to be at an intermediate stage, approximately around TRL 4 to 6. This classification is due to the successful demonstration of these enzymes in controlled environments, showcasing their potential in DNA synthesis and repair, next-generation sequencing, and biomanufacturing processes. However, the reason it has not reached higher TRLs, particularly in novel therapeutic applications or in more complex synthetic biology constructs, primarily lies in technical challenges related to enzyme specificity, efficiency under varying conditions, and integration into multifaceted biological systems. Additionally, the scale-up of processes involving ligases poses significant challenges, including maintaining enzyme activity and stability, which are pivotal for industrial-scale applications. Despite these hurdles, ongoing research and development efforts are focused on engineering ligases with improved properties and exploring innovative delivery mechanisms, indicating a positive trajectory toward higher TRLs in the future.
In the Short-Term, we anticipate significant advancements in ligase enzymes' efficiency and specificity. Researchers are focusing on enhancing these enzymes' capabilities to facilitate quicker and more precise genetic editing. This phase will likely see the development of novel ligase variants, optimized for use in cutting-edge gene therapy techniques, aimed at treating genetic disorders with unprecedented accuracy and minimal off-target effects. Moving into the Mid-Term, the focus will shift towards integrating ligase enzymes into more complex synthetic biology applications. We expect the emergence of bioengineered systems that leverage ligases for the assembly of artificial genomes. This period will also witness the refinement of ligase-driven biotechnologies, enabling the production of novel biomaterials and biofuels, thus contributing significantly to sustainability efforts and the circular economy. In the Long-Term, the horizon expands towards the revolutionary potential of ligase enzymes in terraforming and extraterrestrial biotechnologies. Scientists predict the development of ligase-based systems capable of modifying the genetic makeup of organisms to thrive in non-Earth environments. This ambitious phase aims to pave the way for life support and agricultural systems on other planets, marking a significant leap towards human colonization of the solar system.
Some interesting questions that has been asked about the results you have just received for Ligase
What are related technologies to Ligase?
Based on our calculations related technologies to Ligase are Aromatics, Desiccants, Refrigerants, Resins, Green Chemistry
Who are Start-Ups in the field of Ligase?
Start-Ups who are working in Ligase are
Ligero Logistics
Which industries are mostly working on Ligase?
The most represented industries which are working in Ligase are IT, Software and Services, Other, Construction, Biotechnology, Logistics, Supply Chain and Transportation
How does ensun find these Ligase Companies?
ensun uses an advanced search and ranking system capable of sifting through millions of companies and hundreds of millions of products and services to identify suitable matches. This is achieved by leveraging cutting-edge technologies, including Artificial Intelligence.
