RNA Interference
RNA Interference
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RNA interference (RNAi) is a process that occurs in living cells where the expression of certain genes is suppressed or inhibited by the introduction of small interfering RNA (siRNA) molecules. RNAi acts as a natural defense mechanism against foreign genetic material, such as viruses, and can also be used to regulate gene expression. The siRNA molecules bind to and degrade mRNA, preventing it from being translated into a protein. This process of gene silencing is widely used in the study of gene function and has the potential to be used in the development of new therapeutic treatments.
... Antisense oligonucleotide (ASO) and RNA interference (RNAi)- based therapies have been shown to be effective in isolated cells. However, these therapies are limited by the need for lifelong administration, poor delivery across the blood brain barrier, and passive delivery to target cells in ...
... Assays (qPCR, dPCR, SNP, CNV) CRISPR Genes and Gene Fragments Oligonucleotides Oligo Library Synthesis (OLS) RNA Interference (RNAi, si/shRNA) ...
... We use RNA interference, or RNAi, to create medicines that silence the genes that cause or contribute to disease. Our goal is to provide life-changing therapies to people living with rare and common diseases. ...
... 0 years in GlaxoSmithKline (GSK) before joining AstraZeneca (AZ), working on therapeutic antisense, RNA interference, microRNA, and modified RNA.He now consults for numerous UK-based universities, US- and UK-based investment companies, UK- and non-UK biotech companies, and was involved in ...
... RNA Interference (RNAi) technology has made it possible to effectively regulate gene expression. The application of this technology in the laboratory has given scientists a glimpse into the complex biological systems of humans and mammals alike. The ability of RNAi to knockdown target genes ...
... Represented Dicerna in trade secret litigation regarding RNA interference technology. Settled before trial favorably for Dicerna. ...
... Represented Dicerna in antitrust litigation with its competitor Alnylam in the RNA interference field. Settled favorably for Dicerna. ...
... Etusivu / Promega / RNA Analysis / RNA Interference ...
... NoPass oligonucleotides are a reprogrammable, combinatorial, and flexible platform engineered for robust RNA interference. ...
... We propose an approach to target KRAS effectively in patients using RNA interference. To meet this challenge, we have developed a local prolonged siRNA delivery system (Local Drug EluteR, LODER) shedding siRNA against the mutated KRAS (KRAS-LODER). The KRAS-LODER was assessed for its ...
