Simone Savino - Gecco Biotech
At Gecco Biotech, we are committed to devising and developing sustainable enzymatic solutions for a wide range of fields, including chemistry, pharma and F&F. Our services range from enzyme discovery & engineering to downstream processing. Our extensive knowledge and in-house engineering pipeline ensures you receive a product tailored to your needs, quickly and reliably. Using state of the art expertise, we are able to develop novel enzymes, or improve variants, by improving target processes through engineering of enzymes for increased stability, specificity or activity. We have also built a unique, diverse portfolio of enzymes and cofactors which are readily available. GECCO-enzymes and GECCO-cofactors are offered in a stable form (lyophilized). GECCO-enzymes and GECCO-cofactors are offered as purified products. One type of cofactors offered by GECCO are the deazaflavin cofactors.
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Baeyer-Villiger Monooxygenases (BVMOs) - Gecco Biotech
Baeyer-Villiger monooxygenases (BVMOs) catalyze the oxidation of carbonylic substrates to ester or lactone products using NADPH as electron donor and molecular oxygen as electron acceptor. The emerging picture is that these enzymes are mainly oxygen-activating and “Criegee-stabilizing” catalysts that act on any chemically suitable substrate that can diffuse into the active site, which makes BVMOs versatile tools for biocatalytic applications. Besides Baeyer-Villiger oxidations, these enzymes are used for heteroatom oxidations, with most industrial efforts focused on the oxidation of sulfides, forming chiral sulfoxides. Also oxidations of amines, boron and selenium have been demonstrated. Our collection of BVMOs contains the enzymes listed below, of which a large proportion is in stock as purified enzyme. Our collection of BVMOs is continuously expanded with new enzymes, but also with new mutants with promising characteristics. For several enzymes we have larger libraries that can be screened to fine-tune selectivity. ACMO [Gordonia sp. TY-5] Afl838 [Aspergillus flavus NRRL3357] AlmA [Acinetobacter radioresistens] BVMO 4 [Dietzia sp. D5] BVMO 1 [Rhodococcus jostii RHA1] BVMO 2 [Rhodococcus jostii RHA1] BVMO 3 [Rhodococcus jostii RHA1] BVMO 4 [Rhodococcus jostii RHA1] BVMO 5 [Rhodococcus jostii RHA1] BVMO 6 [Rhodococcus jostii RHA1] BVMO 7 [Rhodococcus jostii RHA1] BVMO 8 [Rhodococcus jostii RHA1] BVMO 9 [Rhodococcus jostii RHA1] BVMO 10 [Rhodococcus jostii RHA1] BVMO 11 [Rhodococcus jostii RHA1] BVMO 12 [Rhodococcus jostii RHA1] BVMO 13 [Rhodococcus jostii RHA1] BVMO 14 [Rhodococcus jostii RHA1] BVMO 15 [Rhodococcus jostii RHA1] BVMO 16 [Rhodococcus jostii RHA1] BVMO 17 [Rhodococcus jostii RHA1] BVMO 18 [Rhodococcus jostii RHA1] BVMO 19 [Rhodococcus jostii RHA1] BVMO 20 [Rhodococcus jostii RHA1] BVMO 21 [Rhodococcus jostii RHA1] BVMO 23 [Rhodococcus jostii RHA1] BVMO 24 [Rhodococcus jostii RHA1] BVMO [Streptomyces aculeolatus] BVMO Af1 [Aspergillus fumigatus Af293] BVMO ETaA [Mycobacterium tuberculosis H37Rv] CAMO [Ilyonectria radicicola] CDMO [Rhodococcus ruber] CHMO [Acinetobacter sp. NCIMB9871] CHMO A255C-A293C (R2) CHMO A325C-L483C (R3) CHMO L323C-A325C (RV6) CHMO [Brachymonas petroleovorans] CHMO [Rhodococcus sp. HI-31] TmCHMO [Thermocrispum municipale] TmCHMO LGY3-4-D11 TmCHMO LGY3-4-E5 TmCHMO LGY3-D-A9 TmCHMO LGY3-D-E1 TmCHMO LGY2-B6 TmCHMO LGY1-492-A7 TmCHMO LGY1-248-D3 TmCHMO LGY1-437-E12 CHMO [Xanthobacter flavus] CmBVMO [Cyanidioschyzon merolae] CPDMO [Pseudomonas sp. HI-70] CPMO [Comamonas sp. NCIMB 9872] CPMO F156L HAPMO [Pseudomonas fluorescens ACB] HtCHMO [Haloterrigena turkmenica] LbBVMO [Leptospira biflexa] ObBVMO [Pseudooceanicola batsensis] / BVMO-Ocean OocK [Serratia plymuthica 4Rx13] OTEMO [Pseudomonas putida ATCC 17453] PAMO [Thermobifida fusca YX] PAMO M446G PAMO P440N PAMO P440L PAMO ΔS441ΔA442 PAMO L443F PAMO A442G PAMO I67T PAMO-STMO chimera PAMO-CHMO chimera PAMO-STMO-PAMO chimera PAMO-Met1 chimera PlBVMO [Parvibaculum lavamentivorans] PockeMO [Thermothelomyces thermophilus] RpBVMO [Rhodococcus pyridinovorans] SAPMO [Comamonas testosteroni] SlPAMO-B [Streptomyces leeuwenhoekii] SlPAMO-E [Streptomyces leeuwenhoekii] STMO [Rhodococcus rhodochrous] TeBVMO [Trichodesmium erythraeum] RhCHMO (thermostable variant - M8B: S534R/E91Q/R280Y/A455V/A115V/N431Y/Q439P/D95H)
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Laccases - Gecco Biotech
Bacterial laccases have proven advantages over fungal and plant counterparts regarding wider pH optimum, higher stability and broader biocatalytic scope. We are offering Bacillus licheniformis ATCC 9945a laccase which exhibits remarkable thermostability and resitance to inactivation by organic solvents (https://doi.org/10.1016/j.molcatb.2016.06.005).
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Oxidases - Gecco Biotech
Oxidases catalyze the oxidation of molecules directly using dioxygen as the electron acceptor. Gecco biotech has an ever increasing collection of these verstatile enzymes; currently available enzymes are listed below. Our flagship oxidase is 5-Hydroxymethylfurfural oxidase (HMFO). This enzyme converts HMF into the PEF monomer FDCA and can be used to make bio-based plastic bottles. Oxidases can be used to create many different valuable products, but also the hydrogen peroxide by-product is of interest, for example for electrochemical or colorimetric sensing. The use of ChitO for the detection of cellulase and chitinise degradation products has been extensively describes. The production of hydrogen peroxide can also be exploited for bleaching or anti-microbial purposes. Alcohol oxidase (AOX) Phanerochaete chrysosporium Alcohol oxidase F101S (AOX-M) Phanerochaete chrysosporium Alditol oxidase (HOT-ALDO) Acidothermus cellulolyticus Alditol oxidase (ALDO) Streptomyces coelicolor A3(2) Chitooligosaccharide oxidase (CHITO) Fusarium graminearum Q268R/G270E/S410R (CHITO-M) Fusarium graminearum Eugenol oxidase (EUGO) Rhodococcus jostii RHA1 5-Hydroxymethylfurfural oxidase (HMFO) Methylovorus strain MP688 Isoamyl alcohol oxidase (IAAO) Aspergillus nidulans A4 Vanillyl alcohol oxidase (VAO) Penicillium simplicissimum 6-Hydroxy-d-nicotine oxidase (6-HDNO) Arthrobacter nicotinovorans Putrescine oxidase (PuO) Rhodococcus erythropolis NCIMB 11540 Putative copper oxidase Thermobifida fusca Cyclohexylamine oxidase (CHAO) Microbacterium oxydans
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Where is Gecco Biotech B.V. located?
The company Gecco Biotech B.V. is located in Groningen, Groningen, Netherlands. It's worth noting that the company may has more corporate locations
How many employees does Gecco Biotech B.V. approximately have?
As of the latest available information Gecco Biotech B.V. has around 1-10 employees worldwide.
In which industries does Gecco Biotech B.V. mainly work?
The company Gecco Biotech B.V. has it's main focus in the industries of Biotechnology
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