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Daresbury, United Kingdom
1-10 Employees
Entropix is an enzyme development company specialising in the directed evolution of high-performance enzymes and biocatalysts. Our mission is to use directed evolution to build on Nature in the smartest possible way. Computational BiologyWe are developing a machine learning platform to predict patterns of evolution and accelerate Nature. Proprietary EnzymesWe are developing a range of proprietary enzymes for various sectors including plastics degradation, diagnostics, and molecular biology research. At the heart of Entropix is its people and the way we work. Visit the Entropix Team page for full biographies. Entropix LimitedLab 124The Heath Business and Technical ParkRuncornCheshireWA7 4QXUK. Entropix is an early-stage enzyme engineering company specialising in the directed evolution of high-performance enzymes and biocatalysts.
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Technology - Entropix - Enzyme Engineering Through Directed Evolution
... Technology - Entropix - Enzyme Engineering Through Directed ...
Menlo Park, United States
11-50 Employees
2017
We are a passionate group of hardware nerds, coders, machine learning engineers, and biologists working to build a better future for humankind. Aether is the first company capable of searching sequence space to find novel biocatalysts.
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Aether Bio — Build the next industrial revolution.
... Solving enzyme engineering as a search problem. ...
Temecula, United States
51-100 Employees
2002
Codexis has engineered IVT enzymes to overcome the obstacles of producing high-quality mRNA at commercial scale. At Codexis, we strive to innovate sustainable processes and products, and discover and develop effective therapeutics – all to create a brighter future. Reimagine enzymes as enablers for efficient pharmaceutical manufacturing, sequencing and diagnostic applications, RNA manufacturing and more. Engineered enzymes can overcome current challenges, bottlenecks and enable new methods for product and process innovations. Engineered, high-quality biocatalysts can transform processes with enhanced activity and stability, leading to efficient and sustainable production of pharmaceuticals. The challenges associated with in vitro transcription (IVT) to manufacture large quantities of mRNA requires high performance enzymes that reduce impurities and produce capped, full-length mRNA. High-performing and specifically tailored for life science research needs, our enzyme products improve processivity, boost efficiency and withstand more challenging condition resulting in faster and more versatile workflows and better yields. We offer research and development partnership options to develop and deliver quality engineered enzyme solutions, providing a path to successful commercialization including screening, proof-of-concept, evolution, and options to scale-up and supply custom enzymes.
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CodeEvolver® Technnology Platform | :: Codexis, Inc. (CDXS)
... Powering enzyme engineering ...
Leipzig, Germany
51-100 Employees
2004
Our goal: safe and cost-effective food production to improve human health. Our products for the pharmaceutical industry cover a wide range of applications. We are a highly respectful, diverse community driven primarily by a passion for innovation. All products are developed, produced, and marketed in accordance with our quality management system. One of our enzyme products is produced as a GMP product according to the EU’s GMP requirements for biopharmaceutical industry customers. The long path from inception to final product is fraught with challenges. The company uses world-class enzyme engineering and production technologies to provide its partners in the food and pharmaceutical industries with superior biotechnological solutions for innovative industrial applications. Our enzyme products for the food industry are used for the enzymatic production of food ingredients and additives or as process aids in the production of foods and beverages.
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Interview: How AI is affecting Enzyme Engineering
... We asked Dr Sebastian Bartsch, Head of Bioinformatics at c-LEcta,to explain how artificial intelligence is specifically used to support enzyme engineering. ...
Hangzhou City, China
51-100 Employees
2019
We develop high-flux platform strains and fermentation processes for microbial production of high-performing industrial compounds. Enzymes with high regio- and stereo-selectivity can be evolved. Enzymes with high catalytic activity can efficiently reduce COGS. Enzymes with high stability can tolerate harsh industrial conditions. Strains with balanced pathway flux can eliminate bottlenecks and accumulation of intermediates.
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Bota Bio
... Enzyme Engineering ...
Dusseldorf, Germany
1-10 Employees
2018
Here, at Enzymaster’s headquarters, the company has already gained approximately 237 employees. We are an international team of scientists with longstanding expertise in enzyme engineering, synthetic chemistry, bioinformatics, molecular biology, and process development. Enzymaster always pushes the boundaries of its technology and finds innovative routes to achieve the best results for its customers. Enzymaster’s longstanding experience and knowhow combined with the highest quality and working standards ensures the best results. Enzymaster tailors its services and products individually to reach the customer’s goals in the most efficient and resource-saving way. Our focus lies on the development and commercialization of enzymes for the innovative and sustainable production of API intermediates, fine and commodity chemicals, and compounds applied in consumer goods. For this, we assembled an international team of scientists with longstanding expertise in enzyme engineering, synthetic chemistry, bioinformatics, molecular biology, and process development. This comprehensive knowledge allows us to provide one stop solutions, guiding our customers through the entire development process, starting from the idea, all the way to the commercialization on a hundred to a thousand-ton scale.
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Who we are | enzymaster.de
... We are an international team of scientists with longstanding expertise in enzyme engineering, synthetic chemistry, bioinformatics, molecular biology, and process development. ...
Vienna, Austria
11-50 Employees
2007
Biosynth delivers high-performance enzyme solutions for applications in pharma, biotech, fine chemicals, food & feed, and cosmetics industries. With a portfolio of over 50 enzymes including innovative lipases, beta-lactamases, peroxidases and other enzymes Biosynth has a proven track record of providing customized solutions. As an application-driven provider of tailored enzyme solutions, we work closely with our customers to better understand and fulfill their individual biocatalyst needs. Biosynth is an expert in engineering and developing enzymes for industrial applications, using our proprietary in vivo recombination technology – either alone or in combination with other mutagenesis technologies – to modulate activities of target enzymes in accordance with required specifications. Coupled with high-throughput screening capabilities and assay platforms, we can deliver optimized enzymes with desired properties within agreed timelines.
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EUCODIS Bioscience | Services
... Protein & enzyme engineering ...
Brno, Czechia
11-50 Employees
2006
Enantis is an innovative biotech company that cleverly tackles previously unsolved problems using its proprietary protein engineering platform. In addition, we are currently in preclinical testing phase with FGF2-STAB® as a novel therapeutic solution for hard-to-heal wounds. Enantis is based in Brno, Czech Republic and has a close relationship with Loschmidt Laboratories (Masaryk University), a world-renowned academic institution focused on development of protein engineering software. With both our products and services, we want to create healthier and more sustainable future. Enantis is proudly ISO 9001:2016 certified for the quality management system in the field of research, development and production of proteins. We develop and sell thermostable fibroblast growth factors. We are an exclusive distributor of commercial protein engineering software. We are the world’s only supplier of engineered haloalkane dehalogenases.
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Services - Enantis
... Protein or enzyme engineering of your ...
Shanghai, China
501-1000 Employees
We are committed to the mission that “technological innovation drives the progress of bio-industry and continues to create values for customers.” Today, Hzymes creates five innovative enzyme creation technology platforms to provide the consistent large-scale output of the highest-quality enzymes for customers worldwide. We are committed to fulfilling any demand of our customers and foster the development of biotechnology in the research level.”. We are a team of innovation and inclusion. We are expert in research and development, production, and technical services of IVD raw materials using 5 core technology platforms: deep mining platform for enzyme gene diversity, enzyme structure-function analysis and molecular rational design platform, platform for directed evolution and high-throughput screening of enzyme functions, enzyme large-scale expression and quality control platform, and enzyme application technology and reagent formulation development platform. We believe that not only scientific research and innovation, but the source of vitality builds the foundation for Hzymes sustainable development. With 20 years of experience in technical accumulation, Hzymes Biotechnology Co., Ltd. Hzymes Biotech has established R&D and production bases in Wuhan, Shanghai, Suzhou, and Qingdao. The company is going forward by virtue of multiple technology platforms and multiple products.
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Featured
Hzymes Biotech - decades of experience in enzyme engineering.
... Hzymes Biotech - decades of experience in enzyme engineering. ...
San Francisco, United States
1-10 Employees
2016
Enzyme QMS has everything you need, premarket to postmarket, startup to IPO. Enzyme adapts to your way of working, not the other way around. Enzyme eQMS is flexible and scalable, making it easy to use for startups, yet configurable to meet the needs of the most complex enterprise.
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Enzyme Services: Regulatory / Engineering / Quality Consulting
... Enzyme Services: Regulatory / Engineering / Quality ...
Technologies which have been searched by others and may be interesting for you:
Some interesting numbers and facts about the results you have just received for Enzyme Engineering
| Country with most fitting companies | United States |
| Amount of fitting manufacturers | 27 |
| Amount of suitable service providers | 17 |
| Average amount of employees | 11-50 |
| Oldest suiting company | 2002 |
| Youngest suiting company | 2019 |
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Enzyme engineering is a specialized branch of bioengineering that involves the modification of enzyme structures and functions to create new molecules with desired properties or to enhance existing ones. This field leverages techniques from molecular biology, bioinformatics, and chemical engineering to alter enzymes' catalytic activity, stability, selectivity, or substrate specificity. By manipulating the genetic sequences encoding enzymes, scientists can produce variants with improved performance under industrial conditions, such as higher temperatures or non-natural pH levels, extending their applicability in various sectors including pharmaceuticals, biotechnology, and environmental management. The impact of enzyme engineering is profound, offering eco-friendly alternatives to traditional chemical processes by facilitating reactions under milder conditions, reducing energy consumption, and minimizing waste production. Furthermore, it plays a crucial role in the development of novel therapeutics, including enzyme replacement therapies for genetic disorders, and in the bioconversion of biomass to renewable fuels and chemicals, contributing to the advancement of sustainable energy solutions. Through the design and optimization of enzymes, this field continues to push the boundaries of what is chemically possible, driving innovation in both industrial and medical biotechnology.
1. Enhanced Efficiency
Enzyme engineering enables the development of enzymes with optimized activity and stability under various industrial conditions. This improvement in enzyme performance leads to more efficient biochemical reactions, reducing the time and resources required for processes such as biofuel production, pharmaceutical manufacturing, and waste management.
2. Environmental Benefits
By tailoring enzymes to work effectively at lower temperatures and pH levels, enzyme engineering contributes to significant energy savings and a reduction in the use of harsh chemicals. This shift towards greener alternatives helps in minimizing the environmental footprint of industrial activities, promoting sustainable practices across sectors.
3. Cost Reduction
The enhanced specificity and efficiency of engineered enzymes directly translate into cost savings for industries. By streamlining production processes and reducing the need for expensive chemicals and energy inputs, companies can achieve lower operational costs while maintaining high-quality outputs.
4. Customization and Flexibility
Enzyme engineering offers the unique advantage of customizing enzymes for specific applications. This flexibility allows for the creation of tailor-made solutions that address the precise needs of different industries, enhancing the versatility and applicability of biotechnological processes.
1. Expertise and Experience
Ensure the supplier has a strong background in biotechnology and a track record of successful enzyme engineering projects. Their experience should align with your specific needs.
2. Quality Assurance Systems
Verify that the supplier implements rigorous quality control measures and complies with relevant industry standards to ensure the enzymes' efficacy and safety.
3. Customization Capabilities
The supplier should be able to tailor enzymes to your specific applications, optimizing their performance in your processes.
4. Scalability
Choose a supplier capable of scaling production to meet your demands without compromising quality or increasing costs disproportionately.
5. Technical Support
Look for a supplier that offers comprehensive technical support, including assistance with enzyme application, optimization, and troubleshooting.
6. Cost-Effectiveness
While quality should not be compromised, the supplier must offer competitive pricing and value for money, ensuring your project remains economically viable.
Enzyme engineering has revolutionized the pharmaceutical industry by enabling the production of highly specific drugs. Through the modification of enzymes, companies can create medications that target disease-causing molecules with unprecedented precision, reducing side effects and improving patient outcomes. This application of enzyme engineering ensures that therapeutic agents are more effective and safer, enhancing the quality of healthcare globally. In the biofuel sector, enzyme engineering plays a crucial role in developing more efficient methods of converting biomass into fuel. By optimizing enzymes for specific reactions, scientists can break down plant materials into biofuels more effectively, making the production process both cost-effective and environmentally friendly. This advancement supports the transition towards renewable energy sources, positioning biofuels as a viable alternative to fossil fuels. The food industry benefits from enzyme engineering by improving food processing techniques. Engineered enzymes are used to enhance flavors, textures, and nutritional value, as well as to extend shelf life without the need for artificial preservatives. This not only meets consumer demand for healthier, more natural food options but also reduces food waste, contributing to more sustainable food production practices. In textile manufacturing, enzyme engineering has led to the development of eco-friendly processing methods. Enzymes are employed to treat fabrics, resulting in softer textures, brighter colors, and reduced environmental impact compared to traditional chemical treatments. This approach aligns with growing consumer preferences for sustainable and ethically produced goods, offering textile companies a competitive edge in the market.
Enzyme engineering currently sits at various Technology Readiness Levels (TRLs), ranging from 4 to 7, depending on the specific application and development stage. This broad TRL spectrum is due to the extensive research and development that enzyme engineering has undergone, moving from fundamental research to validation in relevant environments. At the lower end (TRL 4), enzyme engineering involves the validation of lab-scale technologies, where enzymes are modified through techniques like directed evolution or rational design to enhance their stability, specificity, or activity. These modifications are crucial for applications in industries such as pharmaceuticals, biofuels, and waste management. Progressing to TRLs 5 and 6, enzyme engineering demonstrates the ability to function in relevant industrial environments, albeit at a smaller scale. This includes the optimization of enzyme production and purification processes, ensuring that engineered enzymes can be produced cost-effectively and at high yields. At the higher end (TRL 7), enzyme engineering technologies have been validated in operational environments, showcasing their application in pilot-scale projects or in processes under real-world conditions. The disparity in TRL levels reflects the challenges in scaling up enzyme production and maintaining enzyme stability and activity under industrial conditions, alongside the need for continuous refinement of enzyme properties to meet specific application requirements.
In the Short-Term, advancements in enzyme engineering are poised to revolutionize various industries, from pharmaceuticals to biofuels. Immediate focuses include enhancing enzyme stability and activity under extreme conditions, such as high temperatures or acidic environments. This will enable more efficient industrial processes, including the production of biofuels from non-food biomass, thus reducing reliance on fossil fuels and contributing to sustainability efforts. Looking into the Mid-Term, we can anticipate the integration of artificial intelligence and machine learning in enzyme design. This innovative approach will expedite the discovery of novel enzymes with specific functions, potentially transforming the pharmaceutical industry by speeding up drug development processes. Additionally, enzyme engineering will advance waste management techniques, facilitating the breakdown of plastics and other polymers into environmentally friendly byproducts, significantly mitigating pollution. In the Long-Term, enzyme engineering is expected to achieve groundbreaking milestones in human health and environmental conservation. Engineered enzymes could be tailored to target and neutralize pathogens with unprecedented specificity, offering new avenues for disease treatment. Moreover, the development of enzymes capable of efficient carbon capture could play a crucial role in combating climate change, offering a sustainable method to reduce atmospheric CO2 levels. These long-term prospects highlight the transformative potential of enzyme engineering, promising significant impacts across multiple sectors.
Some interesting questions that has been asked about the results you have just received for Enzyme Engineering
What are related technologies to Enzyme Engineering?
Based on our calculations related technologies to Enzyme Engineering are Biomedical (Red), Bioinformatics (Gold), Environmental Biotechnology (Grey), Agricultural Biotechnology (Green), Food Related Biotechnology (Yellow)
Which industries are mostly working on Enzyme Engineering?
The most represented industries which are working in Enzyme Engineering are Biotechnology, Science and Engineering, Health Care, Manufacturing, Professional Services
How does ensun find these Enzyme Engineering Companies?
ensun uses an advanced search and ranking system capable of sifting through millions of companies and hundreds of millions of products and services to identify suitable matches. This is achieved by leveraging cutting-edge technologies, including Artificial Intelligence.
