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Proteovant Therapeutics
Philadelphia, United States
B
11-50 Employees
2021
Key takeaway
The company, Proteovant Therapeutics, is harnessing the power of protein degradation to target and break down disease-causing proteins, thereby addressing critical areas in disease treatment. Their approach combines extensive biological insight and advanced technologies to develop innovative medicines for patients with serious conditions.
Highlighted product
Core business
Proteovant Therapeutics
Profacgen
Shirley, United States
B
- Employees
-
Key takeaway
Profacgen is a leading protein service provider that offers custom protein services, including the production of recombinant proteins and a focus on protein interaction analysis. Their expertise and range of expression systems support advanced research in protein degradation and related biological sciences.
Highlighted product
Core business
Profacgen, Perfect Protein
Protein
London, United Kingdom
A
51-100 Employees
1998
Key takeaway
The company, Protein, focuses on fostering collaboration and innovation by bringing together talented individuals to develop projects that align with their Good Growth Goals.
Highlighted product
Core business
Protein – Protein OS Ltd.
Protein brings together brilliant minds to collaboratively discover, incubate and release projects that align with our Good Growth Goals. We do this by tracking the people and ideas that permeate culture through our Agency, Studios, Supplement, and Journal — something we've been doing since 1997.
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Proteome Sciences
London, United Kingdom
A
11-50 Employees
1993
Key takeaway
The company highlights its expertise in proteomics, particularly in developing innovative assays for protein degraders and PROTACs, which are essential for targeted therapeutics. This focus on protein degradation can significantly enhance the development of effective healthcare solutions.
Highlighted product
Service
Protein Degrader
Proteome Factory AG
Berlin, Germany
A
1-10 Employees
-
Key takeaway
The Proteome Factory AG specializes in proteomics and protein analysis, offering advanced technologies for the investigation of protein behavior, including post-translational modifications. Their expertise in reverse-proteomics and high-sensitivity analyses is particularly relevant for studying protein degradation and understanding the molecular mechanisms of drugs and compounds.
Highlighted product
Core business
Proteome Factory - Proteomics, Protein Analysis and Validation
Creative Proteomics
Shirley, United States
B
51-100 Employees
2005
Key takeaway
Creative Proteomics offers specialized protein digestion services, including unbiased in-gel and in-solution digestion, which are essential for successful protein identification and characterization. Their advanced proteome analysis platform ensures high throughput and sensitivity, catering to the needs of researchers across various industries.
Highlighted product
Service
Protein Digestion Service - Creative Proteomics
Creative Proteomics provides unbiased in-gel and in-solution protein digestion services for successful protein identification and characterization.
Bio-Techne
Minneapolis, United States
B
1001-5000 Employees
1981
Key takeaway
Bio-Techne Corporation offers specialized custom targeted protein degradation services, including PROTAC® discovery and research, which are essential for advancing studies in protein degradation. Their portfolio includes specific tools and reagents that support researchers in this field.
Highlighted product
Service
Custom Targeted Protein Degradation Services | Bio-Techne
Explore custom targeted protein degradation services available from Bio-Teche such as PROTAC® panel builders, custom E3 ligases and degrader building blocks.
Reaction Biology
Malvern, United States
B
101-250 Employees
2001
Key takeaway
The company, Reaction Biology, emphasizes its expertise in drug discovery, particularly through its comprehensive portfolio of protein degradation assays, including PROTAC screening. This aligns with their goal of developing potent drug candidates for cancer treatment.
Highlighted product
Service
Protein Degradation Assays - PROTAC Screening | Reaction Biology
e-Proteins
Gembloux, Belgium
A
1-10 Employees
2012
Key takeaway
e-Proteins specializes in producing avidin derivatives, which are key binding proteins that enhance the performance of various applications. Their commitment to quality and innovative R&D ensures reliable and standardized products that could be integral in applications related to protein degradation.
Highlighted product
Core business
e-Proteins: A Solution of any biotin Binding application
e-Proteins is the world leader in avidin derivatives/binding protein production which are the best alternatives to Streptavidin.
NEOsphere Biotechnologies GmbH
Planegg, Germany
A
1-10 Employees
2022
Key takeaway
NEOsphere Biotechnologies specializes in proteomics-based drug discovery, focusing on developing small molecule degraders as therapeutic agents. Their expertise in deep proteomic screening is instrumental in unlocking the potential of these degraders against previously unexploited disease targets.
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Core business
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Technologies which have been searched by others and may be interesting for you:
Protein degradation is a crucial biological process that involves the breakdown of proteins into their constituent amino acids. This process is essential for maintaining cellular homeostasis, regulating protein levels, and removing damaged or misfolded proteins. Various pathways facilitate protein degradation, including the ubiquitin-proteasome system and autophagy. By controlling the degradation of proteins, cells can respond to environmental changes, manage stress, and regulate metabolic processes effectively. Overall, protein degradation plays a vital role in cellular function and health.
Protein degradation plays a crucial role in maintaining cellular functions by regulating the levels of proteins within the cell. This process helps remove damaged or misfolded proteins, preventing their accumulation, which can lead to cellular stress and disease. Furthermore, by selectively degrading certain proteins, cells can control various signaling pathways and metabolic processes, ensuring proper cellular responses to environmental changes. Additionally, protein degradation is essential for processes such as cell cycle progression, apoptosis, and the immune response. It allows for the recycling of amino acids, contributing to metabolic homeostasis. Overall, effective protein degradation is vital for cellular health and function, underscoring its importance in various biological processes.
Protein degradation research employs several advanced methods to study and quantify the breakdown of proteins. One common approach involves the use of mass spectrometry, which allows researchers to analyze protein fragments, providing insights into the degradation process. This technique is crucial for identifying specific degradation products and understanding their implications in various biological systems. Another important method is fluorescence microscopy, which enables the visualization of protein degradation in live cells. By tagging proteins with fluorescent markers, scientists can monitor their degradation in real-time, offering valuable data on the dynamics of protein turnover. Additionally, techniques like Western blotting are utilized to assess the levels of specific proteins before and after degradation, aiding in the analysis of proteolytic pathways.
Protein degradation is crucial in disease treatment as it helps regulate cellular processes and maintain protein homeostasis. In various diseases, such as cancer and neurodegenerative disorders, the accumulation of misfolded or damaged proteins can lead to cellular dysfunction. Targeting protein degradation pathways allows for the removal of these harmful proteins, thereby restoring normal cellular function. Therapeutic strategies often focus on enhancing the degradation of specific proteins implicated in disease progression. For instance, small molecules that promote the activity of proteasomes or autophagic pathways can be designed to selectively degrade oncogenic proteins, improving patient outcomes. This approach not only aids in clearing toxic proteins but also presents a promising avenue for developing novel treatments that could significantly impact disease management.
Protein degradation in the body is primarily regulated through a series of complex cellular mechanisms. One key process involves the ubiquitin-proteasome pathway, where proteins marked by ubiquitin are targeted for degradation by the proteasome. This system helps control protein levels and removes damaged or misfolded proteins, ensuring cellular health. Additionally, autophagy plays a significant role in protein degradation. This process involves the engulfing of cellular components, including proteins, into autophagosomes that fuse with lysosomes for breakdown. Various signaling pathways, such as those involving mTOR and AMP-activated protein kinase, regulate these processes in response to cellular energy levels and nutrient availability, maintaining a balance between protein synthesis and degradation.
Some interesting numbers and facts about your company results for Protein Degradation
| Country with most fitting companies | United States |
| Amount of fitting manufacturers | 2839 |
| Amount of suitable service providers | 2063 |
| Average amount of employees | 51-100 |
| Oldest suiting company | 1981 |
| Youngest suiting company | 2022 |
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Some interesting questions that has been asked about the results you have just received for Protein Degradation
What are related technologies to Protein Degradation?
Based on our calculations related technologies to Protein Degradation are Biomedical (Red), Bioinformatics (Gold), Environmental Biotechnology (Grey), Agricultural Biotechnology (Green), Food Related Biotechnology (Yellow)
Who are Start-Ups in the field of Protein Degradation?
Start-Ups who are working in Protein Degradation are Proteovant Therapeutics, NEOsphere Biotechnologies GmbH
Which industries are mostly working on Protein Degradation?
The most represented industries which are working in Protein Degradation are Biotechnology, Other, IT, Software and Services, Healthcare, Food and Beverage
How does ensun find these Protein Degradation Companies?
ensun uses an advanced search and ranking system capable of sifting through millions of companies and hundreds of millions of products and services to identify suitable matches. This is achieved by leveraging cutting-edge technologies, including Artificial Intelligence.
