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Évry-Courcouronnes, France
11-50 Employees
2014
At Abolis, we develop fermentation processes (as for wine or beer) based on the capacity of an adapted micro-organism to transform sugar into YOUR molecules of interest. Abolis put its unique TECHNOLOGIES, know-how and our TEAM of experts at the service of your project.
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Solution in Metabolic Engineering for Biosynthesis • Abolis
... Strong Expertise in Metabolic Engineering for Biosynthesis. We have solid in-house know-how and unique tools to design and optimize metabolic pathways transforming sugars into your molecule of interest. ...
Carmel, United States
1-10 Employees
2020
Tom is the Founder of Ramseier Biotech Consulting, Scientific Advisor at Karyosoft, and Adjunct Faculty Member at Ivy Tech Community College.
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About Us | Ramseier Biotech Consulting
... Expert Biotechnology Solutions Metabolic Engineering Synthetic Biology Technology Due Diligence IP/FTO Analysis Regulatory ...
Graz, Austria
1-10 Employees
2022
We provide experimental data that helps manufacturing companies to implement biocatalytic cascades in their production plants. How can biocatalysis make the manufacturing of value-added chemical products more efficient and sustainable, cheaper and cleaner? Thereby, we contribute to the transition toward a greener chemical production. Such systems are difficult to optimize and only yield low product titers. Compatible biocatalysts (enzymes) operate together in a single reaction vessel with high substrate loadings, selectivity and under mild reaction conditions. We identify an ensemble of biocatalysts that could deliver a desired value-added product from preferably renewable starting materials. Is the biocatalyst able to convert a given substrate into the desired product(s)? Biocatalysis is perfectly suited to transform substrates from renewable resources to value-added chemical products.
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Enzyan
... METABOLIC ENGINEERING OF ...
Lugano, Switzerland
1-10 Employees
Parthenogen’s products are protected by patent applications, are manufactured according to full GMP compliance, tested in process and at release, and confirmed by stability programs. Parthenogen’s solutions provide dietary tools to aid well being and healthy ageing. We are paving new and unexplored avenues on the cutting edge of contemporary research. We are committed to human wellbeing and all of our research is open access for the benefit of everyone. Parthenogen is ready to divert part of the profit margins to support independent researchers and non-profit organizations. Apply for parthenogen support, you will be directed to our medical staff that will check your eligibility and actual chance of being helped by our treatment. We are thrilled to invite you to visit our stand at the 40th Annual Meeting…. These micronutrients, besides being essential as build blocks for other molecules, also deliver metabolic signals intended to adapt the metabolism (and the epigenetic regulations) to the environment.
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Home — Parthenogen Europe
... Metabolic Engineering with activated micronutrients. Exploring human metabolism modulating it by means of dietary interventions ...
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Metabolic Engineering
... Metabolic Engineering ...
Basel, Switzerland
1-10 Employees
2011
Optimizing Crucial Drug Manufacturing of APIs with Merck. Acquiring Altar and Circularis to Strengthen Our Capabilities. Ferment 2023 is April 19! Have you registered yet? Enhancing Premium Distilled Alcoholic Beverages with Voodoo Scientific. Biology is the most advanced manufacturing technology on the planet.
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Ginkgo Metabolic Engineering Services for Small Molecules - Ginkgo Bioworks
... Leverage Ginkgo’s expertise in metabolic engineering and our foundry scale to program microorganisms to manufacture your molecule of interest. Have a question or ready […] ...
Madison, United States
1-10 Employees
2007
We are expanding our platform of fermented oils. We create technology to make novel lipids, oils, and drug delivery methods. Thomas Kelleher, a seasoned biotechnologist, boasts over 30 years of leadership in industrial biopharmaceutical production. Jeffries, boasting forty years of expertise in microbial biochemistry, physiology, and yeast metabolic engineering, has spearheaded research and development in renewable fuels, chemicals, and materials.
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About - Xylome
... Xylome uses metabolic engineering to develop high value, sustainable products from non-conventional yeasts. We create technology to make novel lipids, palm oil substitutes, biochemicals and enzymes. Our technology increases the value and diversity of byproducts from industrial yeast ...
Emeryville, United States
11-50 Employees
Our goal is to work with industry to identify and help remove barriers to adopting biomanufacturing technologies. The Agile BioFoundry is a consortium of seven U.S. Department of Energy (DOE) national laboratories that operate as a distributed biofoundry in collaboration with industry and academia. We collaborate with industry and academia to accelerate innovation and adopt new biomanufacturing methods. Develop biomanufacturing tools, processes, and partnerships that enable sustainable industrial production of renewable fuels and chemicals for the nation. We partner with the biomanufacturing industry to accelerate bioproduct development. Help us innovate in synthetic biology and biomanufacturing. Our state-of-the-art capabilities are available to researchers in the public and private sectors.
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Machine Learning - Agile BioFoundry
... Predicting bioengineered systems to drive metabolic engineering ...
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Yeast Metabolic Engineering
... Yeast Metabolic Engineering: Methods and Protocols provides the widely established basic tools used in yeast metabolic engineering, while describing in deeper detail novel and innovative methods that have valuable potential to improve metabolic engineering strategies in ...
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Some interesting numbers and facts about the results you have just received for Metabolig Engineering
| Country with most fitting companies | United States |
| Amount of fitting manufacturers | 12 |
| Amount of suitable service providers | 7 |
| Average amount of employees | 1-10 |
| Oldest suiting company | 2007 |
| Youngest suiting company | 2022 |
Metabolic engineering is a multidisciplinary field that combines principles from chemical engineering, molecular biology, and biochemistry to modify or redesign the metabolic pathways of organisms. Its primary goal is to optimize cellular processes for the efficient production of desired substances, such as pharmaceuticals, chemicals, or biofuels, or to endow organisms with novel functionalities. By manipulating genes that control metabolic pathways, scientists can enhance the production yield of target compounds or enable the biosynthesis of entirely new products. This approach involves the use of advanced tools such as CRISPR-Cas9 for precise genetic editing, computational models for pathway prediction, and bioreactors for scaled-up production. The impact of metabolic engineering is profound, offering sustainable alternatives to traditional chemical synthesis methods, reducing reliance on non-renewable resources, and paving the way for innovations in medical treatments, environmental protection, and industrial processes. Its applications extend to the development of disease-resistant crops, biodegradable plastics, and tailored microbial strains for environmental remediation, highlighting its versatility and potential to address some of the most pressing challenges of the 21st century.
1. Enhanced Efficiency
Metabolic engineering allows for the optimization of biochemical pathways to increase the production efficiency of desired compounds. By redirecting resources within cells, it can produce higher yields of products such as pharmaceuticals, fuels, and chemicals compared to traditional methods.
2. Sustainability
This approach promotes the use of renewable resources and lessens reliance on fossil fuels. By engineering organisms to produce valuable compounds from sustainable sources, metabolic engineering contributes to reducing the environmental footprint of manufacturing processes.
3. Cost-Effectiveness
Through the optimization of production pathways, metabolic engineering can significantly reduce the costs associated with the production of various substances. By increasing yield and reducing the need for expensive feedstocks or energy inputs, it offers a more economically viable option for industries.
4. Customizability
Metabolic engineering provides the flexibility to tailor organisms for the production of specific compounds, enabling the creation of substances that are difficult or impossible to produce through traditional chemical synthesis. This customizability opens up new possibilities in the development of novel drugs and materials.
While evaluating the different suppliers make sure to check the following criteria:
1. Expertise in Metabolic Engineering
Ensure that the supplier has a proven track record in the field of metabolic engineering, demonstrated through successful projects or publications.
2. Advanced Technological Capabilities
Verify that the supplier uses the latest technologies and methodologies in metabolic engineering, such as CRISPR, for precise genetic modifications.
3. Customization and Flexibility
The supplier should offer customized solutions that can be tailored to your specific project needs, demonstrating flexibility in approach and execution.
4. Quality Assurance and Compliance
Check for certifications and adherence to quality standards, ensuring the supplier meets regulatory requirements in the production and modification processes.
5. Collaborative Approach
A supplier who values collaboration will facilitate smoother communication, allowing for a more effective partnership and project success.
6. After-Support Services
Consider the level of post-project support provided, including troubleshooting, additional modifications, or further development services.
Metabolic engineering has become a pivotal tool in biotechnology, reshaping how businesses approach production and innovation across multiple industries. In the pharmaceutical sector, metabolic engineering is instrumental in producing complex molecules for drugs, reducing costs, and speeding up the development of new medications. By manipulating the metabolic pathways in microorganisms, companies can enhance the yield of valuable pharmaceutical compounds, making treatments more accessible. The chemical manufacturing industry also benefits significantly from metabolic engineering. Companies leverage this technology to produce bulk chemicals and materials sustainably. Through engineered microbes, businesses can convert renewable resources into essential chemicals, reducing reliance on fossil fuels and minimizing environmental impact. This application not only supports green chemistry initiatives but also opens up new markets for bio-based products. In the food and beverage sector, metabolic engineering is revolutionizing product development. By modifying the metabolic pathways of yeast and bacteria, manufacturers can create flavors, colors, and nutritional additives naturally, catering to the growing consumer demand for clean-label products. This approach allows for the sustainable production of food ingredients, enhancing both the nutritional value and taste of food and drinks without the need for artificial additives. Each of these use cases underscores metabolic engineering's role in driving innovation, sustainability, and efficiency in business-to-business operations across diverse industries.
Metabolic engineering, a discipline that involves the optimization of genetic and regulatory processes within cells to increase the production of specific substances, currently varies across a range of Technology Readiness Levels (TRLs), primarily between TRL 4 to TRL 6. This variation is due to its application in controlled environments (TRL 4), where basic technological components are integrated for testing, through to environments that emulate real-world conditions (TRL 6). The reasons behind this specific TRL positioning stem from technical challenges such as the complexity of biological systems, the difficulty in accurately predicting metabolic pathways outcomes, and the need for extensive experimentation to validate models and hypotheses in relevant environments. The integration of genetic information and the regulatory processes is intricate, requiring sophisticated tools and methodologies for modification and control. Furthermore, while significant advancements have been made in synthetic biology and computational modeling, which support metabolic engineering, the translation of these advancements into practical, scalable applications is still an ongoing process. The field's current TRL reflects the transition from theoretical understanding and laboratory-based testing to the application and validation of these technologies in real-world scenarios, indicating a maturing yet still developing technology.
In the Short-Term, metabolic engineering is expected to see significant advancements in synthetic biology tools, enabling more precise editing of microbial genomes. This phase focuses on improving the efficiency of bio-production processes for pharmaceuticals, biofuels, and fine chemicals. Enhanced computational models and machine learning algorithms will facilitate the rapid design and testing of modified organisms, leading to increased yields and reduced production costs. Looking towards the Mid-Term, the integration of artificial intelligence (AI) with metabolic engineering will revolutionize the field. AI-driven predictive modeling will allow for the exploration of vast genetic spaces, identifying novel pathways and metabolic reactions that can be exploited for industrial applications. This period will also witness the scaling up of lab successes to industrial levels, with a strong emphasis on sustainability, reducing waste and energy consumption in bio-manufacturing processes. In the Long-Term, metabolic engineering is poised to play a pivotal role in addressing global challenges, including food security, renewable energy, and environmental remediation. The development of designer organisms capable of photosynthesis and nitrogen fixation could lead to breakthroughs in sustainable agriculture and bioenergy. Additionally, the creation of microorganisms designed to degrade plastic and other pollutants offers a promising avenue for mitigating environmental pollution, marking a new era of eco-friendly biotechnological solutions.
