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CirculoGene Theranostics
Birmingham, United States
B
11-50 Employees
2015
Key takeaway
CIRCULOGENE focuses on liquid biopsy services that enhance the detection of cfDNA and preserve fragile cfRNA yields, which may be relevant for studies involving circular RNA. Their advanced technology and proprietary processes contribute to high-sensitivity detection, addressing critical needs in cancer management.
Highlighted product
Core business
CIRCULOGENE - Circulogene
Novogene
Beijing, China
D
501-1000 Employees
2011
Key takeaway
Novogene offers a specialized circular RNA sequencing service (circRNA-seq) that utilizes advanced next-generation sequencing (NGS) technology, enabling comprehensive research into circular RNA. Their commitment to high-quality NGS data and optimized processes ensures reliable scientific outcomes for circRNA investigations.
Highlighted product
Service
Circular RNA Sequencing (circRNA-seq) - Novogene
Novogene’s circRNA sequencing service (circRNA-seq) uses next-generation sequencing (NGS) technology to support a wide range of investigations focused on circRNA.
RNa Partners
Oldsmar, United States
B
11-50 Employees
-
Key takeaway
The company, RNA Partners, specializes in healthcare staffing, focusing on pairing skilled professionals with top facilities. Their expertise in identifying candidates with niche clinical skill sets highlights their commitment to meeting the specific hiring needs of healthcare organizations.
Highlighted product
Core business
RNA Partners - RNA Partners
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Real Seq Biosciences
United States
B
1-10 Employees
2019
Key takeaway
RealSeq Biosciences offers advanced small RNA sequencing products and NGS services, including specialized kits for analyzing small RNAs from various sources like tissues, cells, and biofluids. Their innovative technology ensures broad detection and low bias, making it a valuable resource for small RNA research.
Highlighted product
Product
RealSeq Technology — Real Seq Biosciences
Eupheria Biotech GmbH
Dresden, Germany
A
1-10 Employees
-
Key takeaway
Eupheria Biotech GmbH specializes in RNA interference (RNAi) products, offering endoribonuclease-prepared siRNAs and in-vitro transcribed single-stranded RNA sequences, including those related to SARS-CoV-2. Their innovative esiCRISPR product line also enhances genome engineering tools.
Highlighted product
Product
Individual iB-RNAs - Eupheria Biotech
Northern RNA Inc.
Calgary, Canada
A
11-50 Employees
-
Key takeaway
The company specializes in the production of nucleic acid products, including mRNA, which is relevant to the query about circular RNA. Their focus on scalable manufacturing and end-to-end supply supports innovation in the development of life-enabling therapies.
Highlighted product
Service
SERVICES | Northern RNA
incircular
Amsterdam, Netherlands
A
1-10 Employees
2021
Key takeaway
Incircular specializes in developing robust proteins through its exclusive INCYPRO technology, which involves the in situ cyclization of proteins to enhance their 3D structure stability. This innovative approach may have implications for various applications, potentially including areas related to circular RNA research.
Highlighted product
Core business
Incircular | Robust proteins for biomedical applications
Incircular uses an innovative technology, called in situ cyclization of proteins (INCYPRO), to stabilize the 3D structure of proteins.
Eclipse Bioinnovations
San Diego, United States
B
11-50 Employees
2017
Key takeaway
Eclipsebio is a biotechnology company focused on advancing RNA genomics through innovative technologies and Next Generation Sequencing. Their comprehensive RNA genomics platform supports researchers in developing new RNA therapeutics and understanding RNA beyond traditional sequencing methods.
Highlighted product
Core business
Eclipse Bioinnovations | Robust RNA Genomics Solutions
Previous slide Next slide Eclipsebio offers RNA genomics solutions with Next Generation Sequencing technologies to accelerate the development of
RNA Corporation
United States
B
251-500 Employees
1983
Key takeaway
RNA Corporation is dedicated to innovation in product development, particularly in the hair care field. Their expertise and commitment to quality ensure that they create effective and unique personal care products for their brand partners.
Highlighted product
Service
Services - RNA Corporation
RNA Corporation is a contract manufacturer and provides personal care and beauty products manufacturing, formulation, logistics, regulatory, and packaging design services to our customers.
Connect by Circular Lab
Madrid, Spain
A
11-50 Employees
2020
Key takeaway
Circular-Lab® specializes in digitization and process automation within the healthcare and diagnostic sectors. Their commitment to innovative solutions and data-driven strategies positions them at the forefront of transforming healthcare delivery.
Highlighted product
Core business
Home - Connect by Circular-Lab
Circular-Lab is a company focused on digitization, process automation and traceabilityof the value chain of clinical diagnosis and health.
Technologies which have been searched by others and may be interesting for you:
Circular RNA (circRNA) is a type of non-coding RNA characterized by its covalently closed loop structure, which differentiates it from linear RNA. This unique formation arises from the back-splicing of pre-mRNA, leading to a circular configuration that is more stable and resistant to degradation. CircRNAs play various roles in gene regulation, including acting as sponges for microRNAs, influencing transcription, and interacting with RNA-binding proteins. Their involvement in cellular processes highlights their potential significance in understanding complex diseases and developing therapeutic strategies.
Circular RNA has a unique structure that distinguishes it from linear RNA. While linear RNA consists of a straight chain of nucleotides, circular RNA forms a closed loop, which contributes to its stability and resistance to degradation. This circular configuration allows for distinct biological functions, including regulation of gene expression and acting as a sponge for miRNAs. Furthermore, the circularization process can influence the splicing and localization of RNA, leading to diverse roles in cellular processes that linear RNA may not fulfill.
Circular RNAs play several vital roles in cellular processes. These unique RNA molecules are known for their ability to act as regulatory elements in gene expression. They can function as sponges for microRNAs, effectively sequestering these small RNAs and preventing them from binding to their target mRNAs, which can lead to altered protein production. Additionally, circular RNAs are involved in the regulation of transcription and translation. They can interact with proteins, influencing various signaling pathways and cellular functions. Their stability and resistance to degradation make them valuable for maintaining gene regulation, potentially impacting development, differentiation, and disease processes. This diverse functionality underscores the importance of circular RNAs in cellular biology.
Several techniques are employed to study circular RNA due to its unique structure and function.
1. RNA Sequencing
This high-throughput technique allows researchers to identify and quantify circular RNAs in various biological samples. By using specific methods to enrich for circular forms, it provides comprehensive insights into their expression levels and potential roles.
2. Northern Blotting
This classic technique helps visualize RNA molecules, including circular RNAs. By using specific probes, researchers can confirm the presence and size of circular RNAs, aiding in understanding their characteristics.
3. RT-PCR
Reverse transcription followed by polymerase chain reaction (RT-PCR) is commonly utilized to amplify specific circular RNA sequences. This method helps in validating their expression and studying their functional implications.
4. RNA-FISH
Fluorescence in situ hybridization (FISH) allows for the localization of circular RNAs within cells. This technique provides spatial information about their distribution, which is crucial for understanding their biological functions.
5. Mass Spectrometry
Mass spectrometry can be used to analyze the protein interactions with circular RNAs. This technique helps in identifying binding partners and elucidating the functional roles of circular RNAs in cellular processes.
Circular RNA (circRNA) has emerged as a significant player in various diseases, particularly in cancer and neurodegenerative disorders. These RNA molecules can function as microRNA sponges, sequestering microRNAs and thus regulating gene expression. This regulation can lead to altered cellular processes, contributing to disease progression. In cancer, circRNAs can promote tumor growth and metastasis by modulating signaling pathways. They often exhibit tissue-specific expression patterns, making them potential biomarkers for disease diagnosis and prognosis. Additionally, circRNAs are implicated in neurodegenerative diseases by participating in the regulation of neuronal functions and apoptosis, further highlighting their relevance in disease mechanisms.
Some interesting numbers and facts about your company results for Cirular RNA
| Country with most fitting companies | United States |
| Amount of fitting manufacturers | 4119 |
| Amount of suitable service providers | 3775 |
| Average amount of employees | 11-50 |
| Oldest suiting company | 1983 |
| Youngest suiting company | 2021 |
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Some interesting questions that has been asked about the results you have just received for Cirular RNA
What are related technologies to Cirular RNA?
Based on our calculations related technologies to Cirular RNA are Biomedical (Red), Bioinformatics (Gold), Environmental Biotechnology (Grey), Agricultural Biotechnology (Green), Food Related Biotechnology (Yellow)
Who are Start-Ups in the field of Cirular RNA?
Start-Ups who are working in Cirular RNA are incircular, Connect by Circular Lab
Which industries are mostly working on Cirular RNA?
The most represented industries which are working in Cirular RNA are IT, Software and Services, Biotechnology, Other, Healthcare, Telecommunications
How does ensun find these Cirular RNA Companies?
ensun uses an advanced search and ranking system capable of sifting through millions of companies and hundreds of millions of products and services to identify suitable matches. This is achieved by leveraging cutting-edge technologies, including Artificial Intelligence.
