N4 Pharma

In the body, nucleic acids need to be successfully delivered intracellularly with sufficient drug payload to be effective. Once inside the cell, it is released to deliver a localised response. To date, companies have tended to use existing commercially available delivery systems such as lipid nanoparticles, but unlike Nuvec®, these were not designed for working with nucleic acids and although they can also produce good responses they can also induce release of systemic inflammatory cytokines, meaning the patient can feel unwell, plus they may cause liver toxicity. Nuvec® is safe and well tolerated even at high doses and can be delivered intravenously, sub cutaneously or intra muscular. A new approach to DNA/RNA delivery for cancer therapeutics. Our latest news release for trade media highlights our pre-clinical siRNA delivery systems Nuvec® and LipTide®.