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Inorganic Fullerene Coating For Medical Devices | YEDA Technology Transfer
OverviewImplantable or insertable medical devices must be made of materials with unique properties in addition to biocompatibility to address potential damage from the physiological environment and to maintain their effectiveness over time. For instance, urethral medical devices (e.g., catheters) are damaged by the encrustation of minerals from the urine, which results in their frequent replacement. Various medical applications suffer from excessive friction, severely compromising their function leading to prolonged treatments. Prof. Tenne and his team developed a novel method for coating medical devices using inorganic fullerene-like nanoparticles to increase their lubricity and prevent encrustation. This coating is applicable for various devices such as stents, catheters, dialysis tubes, cannulas, and sutures. , The NeedImplantable or insertable medical devices must be biocompatible and possess specific mechanical properties depending on their designated use. In addition, they should also be resistant to potential damage by the physiological environment to ensure their long-lasting effectiveness. In the case of urethral medical devices (e.g., catheters), their exposure to calcium and phosphate ions from the urine results in the formation of crystals on the biomaterial surface, a process known as encrustation. Encrustation may cause infections and harm the medical device's functionality, resulting in its frequent replacement, which is inconvenient to the patient and costly. Also, excessive friction severely compromises the insertion and retrival of medical devices from narrow constrictions in the body, and leads to pain and morbidity of the paitent. In this context, one of the field's major goals is to search for new products that would generate less friction during insertion and retrival of catheters, endoscopes and laproscopes through narrow natural and purposely cut constrictions in the human body. Additionally, coating of endodontic files (EFs) used for root canal treatment can benefit from this technology as well. Finding a way to reduce file breakage during root canal treatment would greatly influence the costs of treatment and the prognosis of treated teeth stages and conditions. Therefore, there is a need for an efficient, general coating method to increase lubricity, thus preventing encrustation and reducing friction. , The SolutionProf. Reshef Tenne and his team developed a novel method for coating medical devices to reduce friction and increase lubricity using inorganic fullerene-like nanoparticles (IF‑WS2, IF-MoS2) 1,2 , Technology Essence Fullerene-like nanoparticles (i.e., IF-WS2, IF-MoS2) are deposited on top of medical devices and change their surface properties dramatically. These nanoparticles produce coating films with a relatively small tendency to agglomerate. This architecture, together with the low affinity of the nanoparticles towards the environment (due to closed caged moieties which lack dandling bonds), results in their superior lubricity. , Applications and AdvantagesApplications Coating implantable or insertable medical devices such as stents; catheters; dialysis tubes; cannulas; and sutures Advantages Non-toxic Cheap Can be easily applied to existing medical devices Biocompatible – Initial tests in animals suggest safety from toxic effects , References1. Adini AR, Feldman Y, Cohen SR, et al. Alleviating fatigue and failure of NiTi endodontic files by a coating containing inorganic fullerene-like WS 2 nanoparticles. J Mater Res. 2011;26(10):1234-1242. doi:10.1557/jmr.2011.52 2. Goldbart O, Yoffe A, Cohen SR, et al. New Deposition Technique for Metal Films Containing Inorganic Fullerene-Like (IF) Nanoparticles. ChemPhysChem. 2013;14(10):2125-2131. doi:10.1002/cphc.201201003
by Yeda Research and Development Co. Ltd
St. Louis, United States
1-10 Employees
2018
The Pulse NanoMED™ System is a nanoscale interventional tool to help diagnose and treat complex vascular occlusions unreachable with existing treatments. Stroke occurs when there is a halt in blood flow to the brain. In stroke, the Pulse NanoMED™ system assists in the delivery of life-saving therapeutics, in the pursuit of TTR and the restoration of life-saving blood flow. ST-Elevation Myocardial Infarction (STEMI) is a severe type of heart attack caused by a complete blockage of a coronary artery, resulting in a significant reduction or cessation of blood flow to a region of the heart muscle. This blockage typically occurs due to the formation of a blood clot, leading to ischemia and potential damage to the heart tissue. PAD is a common circulatory problem in which narrowed arteries reduce the flow of blood to limbs.
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Euphrates Vascular | Treating Distal Vessel Occlusions | Pulse NanoMED
... Euphrates Vascular is a medical device company using nanotechnology to optimize flow and treat distal vessel occlusions in Acute Ischemic Stroke (AIS), Peripheral Artery Disea and ST Elevated Myocardial Infarction (STEMI). ...
Morrisville, United States
1-10 Employees
2015
Surround Medical Systems is a medical device company that develops cutting edge 3D X-ray imaging systems. Utilizing nanotechnology, we are able to create 3D imaging systems with no motion of the X-ray source. Our employees use stringent policy guidelines to drive focus assuring the X-ray systems we manufacture meet applicable medical, industry, and customer requirements for safety and performance. Our stationary 3D Tomo system provides high resolution images at low radiation dose and the same footprint as conventional 2D systems. Surround Medical Systems' PORTRAY® System has the potential to become the new gold standard for routine screening and diagnostic imaging.
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3D Intraoral X-ray Imaging Systems | Surround Medical
... Nanotechnology in Medical ...
Montreal, Canada
1-10 Employees
2015
Revisiting this innovation, we developed pioneering approaches leading to the creation of innovative and more efficient therapies. We are committed to explore new fields of science and to develop innovative and personalised strategies to significantly improve people’s health.”. Our novel nanoparticles can be used to target and deliver drugs directly to tumor cells but also to design preventive solutions. Desiring to significantly improve the health of the population throughout the world, we are determined to tackle cancer and orphan diseases. The strength and the rapid success of Glycovax Pharma’s projects lies in the unique synergy between two teams with complementary expertise.
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Glycovax Pharma | World's elite in medicinal chemistry
... Glycovax Pharma creates innovative drugs and therapies using the power of medical nanotechnology. Our solutions target cancer and rare diseases. ...
Rishon LeZion, Israel
11-50 Employees
1959
YEDA Technology Transfer from the Weizmann Institute of Science. Yeda Research and Development Company Ltd. is the commercial arm of the Weizmann Institute of Science. Yeda holds an exclusive agreement with the Weizmann Institute to commercialize the unique intellectual property developed by the scientists. The income generated serves to support further basic research and science education. The innovation ecosystem comprises of three separate but interrelated units within the Institute.
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Chemistry and Nanotechnology Medical Devices Inorganic Fullerene Coating For Medical Devices (No. T4-1566)
... Chemistry and Nanotechnology Medical Devices Inorganic Fullerene Coating For Medical Devices (No. T4-1566) ...
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TechNanoIndia | Nanoparticle Manufacturing Company
... Application of Nanotechnology in Medical ...
Los Altos, United States
1-10 Employees
1998
The original mission of EPPIC included the following:. While EPPIC has evolved to become culturally diverse & fully inclusive, its mission has not changed: To advance healthcare by providing entrepreneurship, mentoring and networking opportunities to its member base. EPPIC is a member-based global organization that welcomes everyone with deep passion for healthcare, regardless of professional or educational credentials and cultural background. This passion bonds its members while driving them to nurture innovative ideas and solutions to solve healthcare challenges. Fostering an ecosystem of individuals who are highly motivated & highly passionate about healthcare is the glue that has held EPPIC together and is the inherent value that it will continue to deliver to its member base.
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Kavyon Kheymehdooz - EPPIC
... a senior operational leader in global manufacturing and product development, including Class III medical devices and nanotechnology. Focusing on engineering leadership, his accomplishments include global product transfer of TAVR heart valves, process scale-up of ambitious start-up ...
Peabody, United States
51-100 Employees
2005
Your partner for turn-key product manufacturing, capital equipment manufacturing, assemblies, components and parts, specializing in complex challenges for advanced markets. Optimized materials, specialty coatings, quality manufacturing, and engineered to your substrate handling needs.
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Capability Manufacturing and Assembly Service in Peabody
... Cleanrooms are crucial for nanotechnology, medical and scientific applications requiring a controlled environment free of airborne particles that could potentially damage or contaminate sensitive products. ...
Chennai, India
11-50 Employees
2005
Licensed Proprietry Technology from the University of Missouri, U.S.A. NanOlife is the first company in the world to embrace the highly sophisticated scientific concept of applying Green Nanotechnology to develop Nanomedicine products within the Oncology, Ophthalmology, Antibiotics and Cosmeceuticals space. It all started through Professor Kattesh Katti’s over three decades of research in biomedical sciences. In 2005, National Cancer Institute of the National Institutes of Health of USA invested in Professor Katti’s Nanomedicine Research at the University of Missouri, USA. This investment helped Professor Katti to invent the concept of Green Nanotechnology which allows the application of disease curing phytochemicals to develop varieties of gold and silver nanoparticles for use in cancer therapy, ophthalmology, antibiotics and allied medical applications.
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Nanolife : Nanomedicine Products & Speciality Medical Centre
... NanOlife is the first global company, based in Chennai, to actually implement the principles of Green Nanotechnology for medical applications. ...
Medical Nanotechnology is the use of nanoscale materials, devices, and systems to improve the diagnosis, treatment, and prevention of diseases. It involves the development of tools and techniques to manipulate and image structures at the nanoscale, as well as the use of nanoscale materials for diagnostics, drug delivery, and tissue engineering. The combination of nanotechnology and medicine has the potential to revolutionize healthcare by providing more accurate, personalized, and cost-effective treatments.