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Cell Line Genetics
Madison, United States
B
11-50 Employees
2005
Key takeaway
Cell Line Genetics specializes in cell line characterization services, ensuring the genetic integrity and authentication of cell lines for research and clinical applications. Their expertise and commitment to quality support effective cell line development.
Reference
Core business
Cell Line Characterization Services and Products | Cell Line Genetics, Inc
Bionova Scientific
Fremont, United States
B
11-50 Employees
2014
Key takeaway
Bionova specializes in cell line development, utilizing mammalian cell culture processes to create high-quality working cell lines efficiently. Their expertise in deploying DNA sequences ensures enhanced productivity and speed in the development of mAbs and therapeutic proteins.
Reference
Service
Cell Line Development - Bionova Scientific
Bionova's mammalian cell line development optimally deploys DNA sequences into working cell lines to deliver quality, productivity and speed.
Selexis
Plan-les-Ouates, Switzerland
A
11-50 Employees
2001
Key takeaway
KBI Biopharma offers specialized cell line development services, utilizing established mammalian and microbial recombinant protein expression systems to enable rapid cell line generation. Their commitment to high-quality process development supports efficient manufacturing for therapeutics and vaccines.
Reference
Service
Cell Line Development Services - KBI Biopharma
KBI can apply established mammalian and microbial recombinant protein expression systems to provide rapid cell line generation services.
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AGC Biologics
Bothell, United States
B
501-1000 Employees
2001
Key takeaway
AGC Biologics specializes in cell line development, offering decades of expertise in creating cell production lines for protein biologics using both mammalian and microbial expression systems. Their comprehensive services support the entire drug development process, from initial development to full-scale commercialization.
Reference
Service
Cell Line Development Services | Mammalian, Microbial | AGC Biologics
AGC Biologics has decades of expertise developing cell production lines for protein biologics using mammalian and microbial expression systems.
Samsung BioLogics
Kazan, Russia
C
1001-5000 Employees
2011
Key takeaway
Samsung Biologics offers comprehensive cell line development services, completing the process within three months to produce high-quality, high-titer clones. This capability is part of their integrated solutions that facilitate seamless development and manufacturing for biopharmaceutical products.
Reference
Service
Cell Line Development | CDO | Samsung Biologics | The Leading Global CDMO with End-to-End Services
Through cutting-edge technology, Samsung Biologics cell line development completes within 3 months generating high quality and high titer clones.
GEG-Tech
Villebon-sur-Yvette, France
A
1-10 Employees
2010
Key takeaway
GEG Tech specializes in custom cell line development, emphasizing their extensive experience and commitment to quality in engineering stable cell lines. Their advanced R&D infrastructure and innovative technologies position them as a trusted service provider in this field.
Reference
Service
Custom Cell Lines - Trusted, Experienced Cell Line Development Service
Custom cell line development with fast & guaranteed delivery. Over 15 years experience with thousands of projects successfully delivered. Get in touch today.
Icosagen Group
-
1-10 Employees
1999
Key takeaway
Icosagen offers a specialized stable cell line development service through its IcoCell platform, focusing on GMP-compliant CHO-based systems for the production of recombinant proteins and monoclonal antibodies. Their team of experts is dedicated to addressing the challenges of antibody discovery and ensuring high purity and functionality in protein production.
Reference
Service
Cell line development service – Icosagen CRDMO
GMP-compliant high productivity CHO-based cell line development service for production of recombinant proteins and monoclonal antibodies.
ExcellGene
Monthey, Switzerland
A
11-50 Employees
2001
Key takeaway
ExcellGene is a Swiss biologics CDMO that specializes in cell line development, particularly using CHO and HEK cells, offering services that can create stable cell lines in just five months with significantly higher titers than the industry standard. Their expertise in protein expression and commitment to quality supports life science companies in efficiently progressing from concept to clinical use.
Reference
Service
Cell Line Development | CHO & HEK Cell line development -Excellgene
CHO & HEK cell line development services and process optimization. Stable cell lines in 5 months, at 8x higher titer than industry standard.
Cellaria
Wakefield, United States
B
1-10 Employees
2013
Key takeaway
Cellaria specializes in custom cell line development, offering patient-specific models that enhance cancer research and treatment development. Their innovative approach allows scientists to move beyond traditional testing methods, enabling more effective and personalized strategies for addressing the unique nature of each patient's cancer.
Reference
Core business
Cellaria Biosciences | Custom Cell Line Development
Cellaria provides patient specific, custom cell line development for successful achievements in cancer research. Partner with Cellaria today!
GVK Biosciences
Kallur, India
D
1001-5000 Employees
2001
Key takeaway
Aragen Life Sciences specializes in Cell Line Generation, positioning itself as a key partner for innovative biological solutions from research and development to clinical applications. Their commitment to quality and sustainability underscores their dedication to accelerating the pathway to success for their clients.
Reference
Product
Cell Line Generation - Aragen Life Sciences
Technologies which have been searched by others and may be interesting for you:
Cell line development refers to the process of creating a stable and reproducible cell line that can be used for various applications in biotechnology and pharmaceutical research. This process typically involves the isolation of specific cells, their genetic modification, and subsequent selection of those that exhibit desired characteristics, such as high productivity or resistance to certain conditions. Through cell line development, researchers can produce consistent quantities of proteins, antibodies, or therapeutic compounds. The resulting cell lines are crucial for applications in drug discovery, vaccine development, and the production of biological products, ensuring that scientists have reliable models for their experiments and production processes.
The duration of the Cell Line Development process can vary significantly based on several factors, including the specific requirements of the project and the complexity of the cell line being developed. Typically, this process may take anywhere from several weeks to several months. In general, initial stages like transfection and selection can take a few weeks, while further steps such as characterization and optimization may extend the timeline. Overall, a comprehensive process might range from 3 to 6 months, depending on the efficiency of the methods used and the desired quality of the final cell line.
1. Selection of Host Cell
Choosing the appropriate host cell is crucial for successful cell line development. This selection can significantly impact productivity and protein quality.
2. Transfection
Introducing the desired genetic material into the host cell is the next step. This process can involve various methods such as electroporation or lipofection, which facilitate the uptake of DNA or RNA.
3. Clonal Selection
After transfection, identifying and isolating individual cells that express the desired characteristics is vital. This ensures that the resulting cell line is homogeneous and stable.
4. Expansion and Banking
Once a suitable clone is selected, it is expanded to create a sufficient quantity of cells. These cells are then cryopreserved to create a master cell bank for future use.
5. Characterization
A thorough characterization of the cell line is performed to confirm its identity, stability, and productivity. This includes testing for genetic stability, growth rates, and product quality.
6. Scale-Up
Finally, the cell line is scaled up for production. This step involves optimizing culture conditions to maximize yield before moving to large-scale bioreactor systems for commercial production.
Cell line development plays a crucial role in various aspects of biotechnology. Its primary application is in the production of recombinant proteins, where engineered cell lines are utilized to express proteins for therapeutic use, such as monoclonal antibodies and vaccines. Additionally, it is essential for drug discovery and development, allowing researchers to study disease mechanisms and test potential drug candidates in a controlled environment. Another significant application involves the production of diagnostic reagents, where stable cell lines are used to produce antigens or antibodies necessary for assays. Furthermore, cell line development is vital in cell therapy and regenerative medicine, as it enables the generation of specific cell types for transplantation or tissue engineering purposes. These applications underscore the importance of cell line development in advancing biotechnological innovations.
Several factors significantly influence the success of cell line development. Selection of Cell Type Choosing the appropriate parent cell type is crucial, as it directly affects the growth characteristics and productivity of the derived cell line. Different cell types have distinct growth media requirements and growth rates. Genetic Stability Maintaining genetic stability is essential for reproducibility and consistency of results. Variability in the genetic makeup can lead to differences in product quality and yield. Culture Conditions Optimizing culture conditions, including temperature, pH, and nutrient supply, plays a vital role in enhancing cell growth and productivity. These parameters must be fine-tuned for the specific cell line being developed. Regulatory Compliance Adhering to regulatory standards ensures that the developed cell lines meet safety and efficacy requirements. This compliance is necessary for moving forward in research and development phases. Scale-Up Potential The ability to scale the production process from laboratory to industrial levels is a key factor. This includes ensuring that the cell line can be grown in bioreactors efficiently while maintaining desired characteristics.
Some interesting numbers and facts about your company results for Cell Line Development
| Country with most fitting companies | United States |
| Amount of fitting manufacturers | 6395 |
| Amount of suitable service providers | 5889 |
| Average amount of employees | 11-50 |
| Oldest suiting company | 1999 |
| Youngest suiting company | 2014 |
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Some interesting questions that has been asked about the results you have just received for Cell Line Development
What are related technologies to Cell Line Development?
Based on our calculations related technologies to Cell Line Development are Biomedical (Red), Bioinformatics (Gold), Environmental Biotechnology (Grey), Agricultural Biotechnology (Green), Food Related Biotechnology (Yellow)
Which industries are mostly working on Cell Line Development?
The most represented industries which are working in Cell Line Development are Biotechnology, Other, Pharmaceuticals, IT, Software and Services, Medical
How does ensun find these Cell Line Development Companies?
ensun uses an advanced search and ranking system capable of sifting through millions of companies and hundreds of millions of products and services to identify suitable matches. This is achieved by leveraging cutting-edge technologies, including Artificial Intelligence.
